Order and disorder bound together in SARS-CoV-2 Nsp1 suppress host translation

In this issue of Structure, Wang et al. investigate the interplay between folded and disordered regions of the SARS-CoV-2 non-structural protein 1 (Nsp1) that promotes the suppression of host protein translation. Their investigation will lead to novel avenues to therapeutically target critical viral...

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Detalles Bibliográficos
Autores principales: Libich, David S., Baudin, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893522/
https://www.ncbi.nlm.nih.gov/pubmed/36736295
http://dx.doi.org/10.1016/j.str.2023.01.004
Descripción
Sumario:In this issue of Structure, Wang et al. investigate the interplay between folded and disordered regions of the SARS-CoV-2 non-structural protein 1 (Nsp1) that promotes the suppression of host protein translation. Their investigation will lead to novel avenues to therapeutically target critical viral functions necessary for host immune-response suppression.

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