The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model

BACKGROUND: The CRISPR-Cas13 system is an RNA-guided RNA-targeting system and has been widely used in transcriptome engineering with potentially important clinical applications. However, it is still controversial whether Cas13 exhibits collateral activity in mammalian cells. RESULTS: Here, we find t...

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Detalles Bibliográficos
Autores principales: Li, Yunfei, Xu, Junjie, Guo, Xuefei, Li, Zhiwei, Cao, Lili, Liu, Shengde, Guo, Ying, Wang, Guodong, Luo, Yujie, Zhang, Zeming, Wei, Xuemei, Zhao, Yingchi, Liu, Tongtong, Wang, Xiao, Xia, Huawei, Kuang, Ming, Guo, Qirui, Li, Junhong, Chen, Luoying, Wang, Yibing, Li, Qi, Wang, Fengchao, Liu, Qinghua, You, Fuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893547/
https://www.ncbi.nlm.nih.gov/pubmed/36726140
http://dx.doi.org/10.1186/s13059-023-02860-w

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