Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex

BACKGROUND: Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that is associated with neurological symptoms, including autism spectrum disorder. Tuberous sclerosis complex is caused by pathogenic germline mutations of either the TSC1 or TSC2 gene, but somatic mutations were identifi...

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Detalles Bibliográficos
Autores principales: Kashii, Hirofumi, Kasai, Shinya, Sato, Atsushi, Hagino, Yoko, Nishito, Yasumasa, Kobayashi, Toshiyuki, Hino, Okio, Mizuguchi, Masashi, Ikeda, Kazutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893559/
https://www.ncbi.nlm.nih.gov/pubmed/36732866
http://dx.doi.org/10.1186/s40246-023-00450-2

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