Common mouse models of tauopathy reflect early but not late human disease

BACKGROUND: Mouse models that overexpress human mutant Tau (P301S and P301L) are commonly used in preclinical studies of Alzheimer’s Disease (AD) and while several drugs showed therapeutic effects in these mice, they were ineffective in humans. This leads to the question to which extent the murine m...

Descripción completa

Detalles Bibliográficos
Autores principales: Wenger, Kathrin, Viode, Arthur, Schlaffner, Christoph N., van Zalm, Patrick, Cheng, Long, Dellovade, Tammy, Langlois, Xavier, Bannon, Anthony, Chang, Rui, Connors, Theresa R., Oakley, Derek, Renard, Bernhard, Rappsilber, Juri, Hyman, Bradley, Steen, Hanno, Steen, Judith A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893608/
https://www.ncbi.nlm.nih.gov/pubmed/36732784
http://dx.doi.org/10.1186/s13024-023-00601-y

Ejemplares similares

Ejemplares similares