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The “SALPARE study” of spontaneous intracerebral hemorrhage: part 1

BACKGROUND: Spontaneous intracerebral hemorrhage (ICH) is a devastating type of stroke with a huge impact on patients and families. Expanded use of oral anticoagulants and ageing population might contribute to an epidemiological change. In view of these trends, we planned a study to obtain a contemp...

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Autores principales: De Rosa, Ludovica, Manara, Renzo, Vodret, Francesca, Kulyk, Caterina, Montano, Florian, Pieroni, Alessio, Viaro, Federica, Zedde, Maria Luisa, Napoletano, Rosa, Ermani, Mario, Baracchini, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893659/
https://www.ncbi.nlm.nih.gov/pubmed/36726162
http://dx.doi.org/10.1186/s42466-023-00231-1
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author De Rosa, Ludovica
Manara, Renzo
Vodret, Francesca
Kulyk, Caterina
Montano, Florian
Pieroni, Alessio
Viaro, Federica
Zedde, Maria Luisa
Napoletano, Rosa
Ermani, Mario
Baracchini, Claudio
author_facet De Rosa, Ludovica
Manara, Renzo
Vodret, Francesca
Kulyk, Caterina
Montano, Florian
Pieroni, Alessio
Viaro, Federica
Zedde, Maria Luisa
Napoletano, Rosa
Ermani, Mario
Baracchini, Claudio
author_sort De Rosa, Ludovica
collection PubMed
description BACKGROUND: Spontaneous intracerebral hemorrhage (ICH) is a devastating type of stroke with a huge impact on patients and families. Expanded use of oral anticoagulants and ageing population might contribute to an epidemiological change. In view of these trends, we planned a study to obtain a contemporary picture and identify early prognostic factors to improve secondary prevention. METHODS: This multicenter prospective cohort study included consecutive adult patients with non-traumatic ICH admitted to three academic Italian hospitals (Salerno, Padova, Reggio Emilia) over a 2-year period. Demographic characteristics, vascular risk profile, clinical data and main radiological characteristics were correlated to 90-day clinical outcome. RESULTS: Out of 682 patients [mean age: 73 ± 14 years; 316 (46.3%) females] enrolled in this study, 40% died [86/180 (47.8%) in Salerno, 120/320 (37.5%) in Padova, 67/182 (36.8%) in Reggio Emilia; p < 0.05)] and 36% were severely disabled at 90 days. Several factors were associated with a higher risk of poor functional outcome such as antithrombotic drug use, hyperglycemia, previous cerebrovascular accident, low platelet count, and pontine/massive/intraventricular hemorrhage. However, at multivariate analysis only pre-ICH mRS score (OR 30.84), GCS score at presentation (OR 11.88), initial hematoma volume (OR 29.71), and NIHSS score at presentation (OR 25.89) were independent predictors of death and poor functional outcome. CONCLUSION: Despite the heterogeneity among centers, this study on ICH has identified four simple prognostic factors that can independently predict patients outcome, stratify their risk, and guide their management. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s42466-023-00231-1.
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spelling pubmed-98936592023-02-03 The “SALPARE study” of spontaneous intracerebral hemorrhage: part 1 De Rosa, Ludovica Manara, Renzo Vodret, Francesca Kulyk, Caterina Montano, Florian Pieroni, Alessio Viaro, Federica Zedde, Maria Luisa Napoletano, Rosa Ermani, Mario Baracchini, Claudio Neurol Res Pract Research Article BACKGROUND: Spontaneous intracerebral hemorrhage (ICH) is a devastating type of stroke with a huge impact on patients and families. Expanded use of oral anticoagulants and ageing population might contribute to an epidemiological change. In view of these trends, we planned a study to obtain a contemporary picture and identify early prognostic factors to improve secondary prevention. METHODS: This multicenter prospective cohort study included consecutive adult patients with non-traumatic ICH admitted to three academic Italian hospitals (Salerno, Padova, Reggio Emilia) over a 2-year period. Demographic characteristics, vascular risk profile, clinical data and main radiological characteristics were correlated to 90-day clinical outcome. RESULTS: Out of 682 patients [mean age: 73 ± 14 years; 316 (46.3%) females] enrolled in this study, 40% died [86/180 (47.8%) in Salerno, 120/320 (37.5%) in Padova, 67/182 (36.8%) in Reggio Emilia; p < 0.05)] and 36% were severely disabled at 90 days. Several factors were associated with a higher risk of poor functional outcome such as antithrombotic drug use, hyperglycemia, previous cerebrovascular accident, low platelet count, and pontine/massive/intraventricular hemorrhage. However, at multivariate analysis only pre-ICH mRS score (OR 30.84), GCS score at presentation (OR 11.88), initial hematoma volume (OR 29.71), and NIHSS score at presentation (OR 25.89) were independent predictors of death and poor functional outcome. CONCLUSION: Despite the heterogeneity among centers, this study on ICH has identified four simple prognostic factors that can independently predict patients outcome, stratify their risk, and guide their management. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s42466-023-00231-1. BioMed Central 2023-02-02 /pmc/articles/PMC9893659/ /pubmed/36726162 http://dx.doi.org/10.1186/s42466-023-00231-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
De Rosa, Ludovica
Manara, Renzo
Vodret, Francesca
Kulyk, Caterina
Montano, Florian
Pieroni, Alessio
Viaro, Federica
Zedde, Maria Luisa
Napoletano, Rosa
Ermani, Mario
Baracchini, Claudio
The “SALPARE study” of spontaneous intracerebral hemorrhage: part 1
title The “SALPARE study” of spontaneous intracerebral hemorrhage: part 1
title_full The “SALPARE study” of spontaneous intracerebral hemorrhage: part 1
title_fullStr The “SALPARE study” of spontaneous intracerebral hemorrhage: part 1
title_full_unstemmed The “SALPARE study” of spontaneous intracerebral hemorrhage: part 1
title_short The “SALPARE study” of spontaneous intracerebral hemorrhage: part 1
title_sort “salpare study” of spontaneous intracerebral hemorrhage: part 1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893659/
https://www.ncbi.nlm.nih.gov/pubmed/36726162
http://dx.doi.org/10.1186/s42466-023-00231-1
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