Cargando…
Transcutaneous electrical acupoint stimulation induced sedative effects in healthy volunteers: A resting-state fMRI study
BACKGROUND: Previous studies indicated the sedative effect of acupoint stimulation. However, its mechanism remains unclear. This study aimed to investigate the sedative effect of transcutaneous electrical acupoint stimulation (TEAS) and to explore the brain regions involved in this effect in healthy...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893780/ https://www.ncbi.nlm.nih.gov/pubmed/36741778 http://dx.doi.org/10.3389/fnhum.2022.843186 |
_version_ | 1784881600513703936 |
---|---|
author | Lu, Zhihong Huo, Tingting Deng, Jiao Guo, Fan Liu, Kang Liu, Peng Wang, Qiang Xiong, Lize |
author_facet | Lu, Zhihong Huo, Tingting Deng, Jiao Guo, Fan Liu, Kang Liu, Peng Wang, Qiang Xiong, Lize |
author_sort | Lu, Zhihong |
collection | PubMed |
description | BACKGROUND: Previous studies indicated the sedative effect of acupoint stimulation. However, its mechanism remains unclear. This study aimed to investigate the sedative effect of transcutaneous electrical acupoint stimulation (TEAS) and to explore the brain regions involved in this effect in healthy volunteers using functional magnetic resonance imaging (fMRI) techniques. METHODS: In this randomized trial, 26 healthy volunteers were randomly assigned to the TEAS group (receiving 30 min of acupoint stimulation at HT7/PC4) and the control group. fMRI was conducted before and after the intervention. The primary outcome was the BIS value during the intervention. Secondary outcomes included the amplitude of low-frequency fluctuation (ALFF) and region of interest (ROI)-based functional connectivity (FC) showed by fMRI. RESULTS: In healthy volunteers, compared with the control group, ALFF values in the TEAS-treated volunteers decreased in the left thalamus, right putamen, and midbrain, while they increased in the left orbitofrontal cortex. More FC existed between the thalamus and the insula, middle cingulate cortex, somatosensory cortex, amygdala, and putamen in subjects after TEAS treatment compared with subjects that received non-stimulation. In addition, ALFF values of the thalamus positively correlated with BIS in both groups. CONCLUSION: Transcutaneous electrical acupoint stimulation could induce a sedative effect in healthy volunteers, and inhibition of the thalamus was among its possible mechanisms. CLINICAL TRIAL REGISTRATION: www.ClinicalTrials.gov; identifier: NCT01896063. |
format | Online Article Text |
id | pubmed-9893780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98937802023-02-03 Transcutaneous electrical acupoint stimulation induced sedative effects in healthy volunteers: A resting-state fMRI study Lu, Zhihong Huo, Tingting Deng, Jiao Guo, Fan Liu, Kang Liu, Peng Wang, Qiang Xiong, Lize Front Hum Neurosci Human Neuroscience BACKGROUND: Previous studies indicated the sedative effect of acupoint stimulation. However, its mechanism remains unclear. This study aimed to investigate the sedative effect of transcutaneous electrical acupoint stimulation (TEAS) and to explore the brain regions involved in this effect in healthy volunteers using functional magnetic resonance imaging (fMRI) techniques. METHODS: In this randomized trial, 26 healthy volunteers were randomly assigned to the TEAS group (receiving 30 min of acupoint stimulation at HT7/PC4) and the control group. fMRI was conducted before and after the intervention. The primary outcome was the BIS value during the intervention. Secondary outcomes included the amplitude of low-frequency fluctuation (ALFF) and region of interest (ROI)-based functional connectivity (FC) showed by fMRI. RESULTS: In healthy volunteers, compared with the control group, ALFF values in the TEAS-treated volunteers decreased in the left thalamus, right putamen, and midbrain, while they increased in the left orbitofrontal cortex. More FC existed between the thalamus and the insula, middle cingulate cortex, somatosensory cortex, amygdala, and putamen in subjects after TEAS treatment compared with subjects that received non-stimulation. In addition, ALFF values of the thalamus positively correlated with BIS in both groups. CONCLUSION: Transcutaneous electrical acupoint stimulation could induce a sedative effect in healthy volunteers, and inhibition of the thalamus was among its possible mechanisms. CLINICAL TRIAL REGISTRATION: www.ClinicalTrials.gov; identifier: NCT01896063. Frontiers Media S.A. 2023-01-19 /pmc/articles/PMC9893780/ /pubmed/36741778 http://dx.doi.org/10.3389/fnhum.2022.843186 Text en Copyright © 2023 Lu, Huo, Deng, Guo, Liu, Liu, Wang and Xiong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Human Neuroscience Lu, Zhihong Huo, Tingting Deng, Jiao Guo, Fan Liu, Kang Liu, Peng Wang, Qiang Xiong, Lize Transcutaneous electrical acupoint stimulation induced sedative effects in healthy volunteers: A resting-state fMRI study |
title | Transcutaneous electrical acupoint stimulation induced sedative effects in healthy volunteers: A resting-state fMRI study |
title_full | Transcutaneous electrical acupoint stimulation induced sedative effects in healthy volunteers: A resting-state fMRI study |
title_fullStr | Transcutaneous electrical acupoint stimulation induced sedative effects in healthy volunteers: A resting-state fMRI study |
title_full_unstemmed | Transcutaneous electrical acupoint stimulation induced sedative effects in healthy volunteers: A resting-state fMRI study |
title_short | Transcutaneous electrical acupoint stimulation induced sedative effects in healthy volunteers: A resting-state fMRI study |
title_sort | transcutaneous electrical acupoint stimulation induced sedative effects in healthy volunteers: a resting-state fmri study |
topic | Human Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893780/ https://www.ncbi.nlm.nih.gov/pubmed/36741778 http://dx.doi.org/10.3389/fnhum.2022.843186 |
work_keys_str_mv | AT luzhihong transcutaneouselectricalacupointstimulationinducedsedativeeffectsinhealthyvolunteersarestingstatefmristudy AT huotingting transcutaneouselectricalacupointstimulationinducedsedativeeffectsinhealthyvolunteersarestingstatefmristudy AT dengjiao transcutaneouselectricalacupointstimulationinducedsedativeeffectsinhealthyvolunteersarestingstatefmristudy AT guofan transcutaneouselectricalacupointstimulationinducedsedativeeffectsinhealthyvolunteersarestingstatefmristudy AT liukang transcutaneouselectricalacupointstimulationinducedsedativeeffectsinhealthyvolunteersarestingstatefmristudy AT liupeng transcutaneouselectricalacupointstimulationinducedsedativeeffectsinhealthyvolunteersarestingstatefmristudy AT wangqiang transcutaneouselectricalacupointstimulationinducedsedativeeffectsinhealthyvolunteersarestingstatefmristudy AT xionglize transcutaneouselectricalacupointstimulationinducedsedativeeffectsinhealthyvolunteersarestingstatefmristudy |