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Cell-Based Drug Delivery Systems with Innate Homing Capability as a Novel Nanocarrier Platform

Nanoparticle-based drug delivery systems have been designed to treat various diseases. However, many problems remain, such as inadequate tumor targeting and poor therapeutic outcomes. To overcome these obstacles, cell-based drug delivery systems have been developed. Candidates for cell-mediated drug...

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Detalles Bibliográficos
Autores principales: Choi, Anseo, Javius-Jones, Kaila, Hong, Seungpyo, Park, Hansoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893846/
https://www.ncbi.nlm.nih.gov/pubmed/36742991
http://dx.doi.org/10.2147/IJN.S394389
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author Choi, Anseo
Javius-Jones, Kaila
Hong, Seungpyo
Park, Hansoo
author_facet Choi, Anseo
Javius-Jones, Kaila
Hong, Seungpyo
Park, Hansoo
author_sort Choi, Anseo
collection PubMed
description Nanoparticle-based drug delivery systems have been designed to treat various diseases. However, many problems remain, such as inadequate tumor targeting and poor therapeutic outcomes. To overcome these obstacles, cell-based drug delivery systems have been developed. Candidates for cell-mediated drug delivery include blood cells, immune cells, and stem cells with innate tumor tropism and low immunogenicity; they act as a disguise to deliver the therapeutic payload. In drug delivery systems, therapeutic agents are encapsulated intracellularly or attached to the surface of the plasma membrane and transported to the desired site. Here, we review the pros and cons of cell-based therapies and discuss their homing mechanisms in the tumor microenvironment. In addition, different strategies to load therapeutic agents inside or on the surface of circulating cells and the current applications for a wide range of disease treatments are summarized.
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spelling pubmed-98938462023-02-03 Cell-Based Drug Delivery Systems with Innate Homing Capability as a Novel Nanocarrier Platform Choi, Anseo Javius-Jones, Kaila Hong, Seungpyo Park, Hansoo Int J Nanomedicine Review Nanoparticle-based drug delivery systems have been designed to treat various diseases. However, many problems remain, such as inadequate tumor targeting and poor therapeutic outcomes. To overcome these obstacles, cell-based drug delivery systems have been developed. Candidates for cell-mediated drug delivery include blood cells, immune cells, and stem cells with innate tumor tropism and low immunogenicity; they act as a disguise to deliver the therapeutic payload. In drug delivery systems, therapeutic agents are encapsulated intracellularly or attached to the surface of the plasma membrane and transported to the desired site. Here, we review the pros and cons of cell-based therapies and discuss their homing mechanisms in the tumor microenvironment. In addition, different strategies to load therapeutic agents inside or on the surface of circulating cells and the current applications for a wide range of disease treatments are summarized. Dove 2023-01-29 /pmc/articles/PMC9893846/ /pubmed/36742991 http://dx.doi.org/10.2147/IJN.S394389 Text en © 2023 Choi et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Choi, Anseo
Javius-Jones, Kaila
Hong, Seungpyo
Park, Hansoo
Cell-Based Drug Delivery Systems with Innate Homing Capability as a Novel Nanocarrier Platform
title Cell-Based Drug Delivery Systems with Innate Homing Capability as a Novel Nanocarrier Platform
title_full Cell-Based Drug Delivery Systems with Innate Homing Capability as a Novel Nanocarrier Platform
title_fullStr Cell-Based Drug Delivery Systems with Innate Homing Capability as a Novel Nanocarrier Platform
title_full_unstemmed Cell-Based Drug Delivery Systems with Innate Homing Capability as a Novel Nanocarrier Platform
title_short Cell-Based Drug Delivery Systems with Innate Homing Capability as a Novel Nanocarrier Platform
title_sort cell-based drug delivery systems with innate homing capability as a novel nanocarrier platform
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893846/
https://www.ncbi.nlm.nih.gov/pubmed/36742991
http://dx.doi.org/10.2147/IJN.S394389
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