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Characterization and Treatment of Spinal Tumors

The prevalence of spinal tumors is rare in comparison to brain tumors which encompass most central nervous system tumors. Tumors of the spine can be divided into primary and metastatic tumors with the latter being the most common presentation. Primary tumors are subdivided based on their location on...

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Autores principales: Amadasu, Efosa, Panther, Eric, Lucke-Wold, Brandon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893847/
https://www.ncbi.nlm.nih.gov/pubmed/36741203
http://dx.doi.org/10.1007/s44231-022-00014-3
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author Amadasu, Efosa
Panther, Eric
Lucke-Wold, Brandon
author_facet Amadasu, Efosa
Panther, Eric
Lucke-Wold, Brandon
author_sort Amadasu, Efosa
collection PubMed
description The prevalence of spinal tumors is rare in comparison to brain tumors which encompass most central nervous system tumors. Tumors of the spine can be divided into primary and metastatic tumors with the latter being the most common presentation. Primary tumors are subdivided based on their location on the spinal column and in the spinal cord into intramedullary, intradural extramedullary, and primary bone tumors. Back pain is a common presentation in spine cancer patients; however, other radicular pain may be present. Magnetic resonance imaging (MRI) is the imaging modality of choice for intradural extramedullary and intramedullary tumors. Plain radiographs are used in the initial diagnosis of primary bone tumors while Computed tomography (CT) and MRI may often be necessary for further characterization. Complete surgical resection is the treatment of choice for spinal tumors and may be curative for well circumscribed lesions. However, intralesional resection along with adjuvant radiation and chemotherapy can be indicated for patients that would experience increased morbidity from damage to nearby neurological structures caused by resection with wide margins. Even with the current treatment options, the prognosis for aggressive spinal cancer remains poor. Advances in novel treatments including molecular targeting, immunotherapy and stem cell therapy provide the potential for greater control of malignant and metastatic tumors of the spine.
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spelling pubmed-98938472023-02-02 Characterization and Treatment of Spinal Tumors Amadasu, Efosa Panther, Eric Lucke-Wold, Brandon Intensive Care Res Article The prevalence of spinal tumors is rare in comparison to brain tumors which encompass most central nervous system tumors. Tumors of the spine can be divided into primary and metastatic tumors with the latter being the most common presentation. Primary tumors are subdivided based on their location on the spinal column and in the spinal cord into intramedullary, intradural extramedullary, and primary bone tumors. Back pain is a common presentation in spine cancer patients; however, other radicular pain may be present. Magnetic resonance imaging (MRI) is the imaging modality of choice for intradural extramedullary and intramedullary tumors. Plain radiographs are used in the initial diagnosis of primary bone tumors while Computed tomography (CT) and MRI may often be necessary for further characterization. Complete surgical resection is the treatment of choice for spinal tumors and may be curative for well circumscribed lesions. However, intralesional resection along with adjuvant radiation and chemotherapy can be indicated for patients that would experience increased morbidity from damage to nearby neurological structures caused by resection with wide margins. Even with the current treatment options, the prognosis for aggressive spinal cancer remains poor. Advances in novel treatments including molecular targeting, immunotherapy and stem cell therapy provide the potential for greater control of malignant and metastatic tumors of the spine. 2022-12 2022-09-08 /pmc/articles/PMC9893847/ /pubmed/36741203 http://dx.doi.org/10.1007/s44231-022-00014-3 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Amadasu, Efosa
Panther, Eric
Lucke-Wold, Brandon
Characterization and Treatment of Spinal Tumors
title Characterization and Treatment of Spinal Tumors
title_full Characterization and Treatment of Spinal Tumors
title_fullStr Characterization and Treatment of Spinal Tumors
title_full_unstemmed Characterization and Treatment of Spinal Tumors
title_short Characterization and Treatment of Spinal Tumors
title_sort characterization and treatment of spinal tumors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893847/
https://www.ncbi.nlm.nih.gov/pubmed/36741203
http://dx.doi.org/10.1007/s44231-022-00014-3
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