Sporadic Metastatic Malignant Peripheral Nerve Sheath Tumour with an NF1 Mutation Responding to Trametinib: A Case Report

Sporadically occurring malignant peripheral nerve sheath tumours (MPNSTs) can have a variety of genomic alterations including altered NF1, leading to activation of the RAS-RAF-MEK-ERK signalling pathway. Trametinib is an inhibitor of MEK1 and MEK2. Here we present a case of a patient diagnosed with...

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Detalles Bibliográficos
Autores principales: Hitchen, Nadia, Cross, Matthew, Laking, George, Connor, Joanna, Korenbaum, Clement
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by S. Karger AG 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893996/
https://www.ncbi.nlm.nih.gov/pubmed/36743881
http://dx.doi.org/10.1159/000528743

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