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Dual inhibition of HSF1 and DYRK2 impedes cancer progression

Preserving proteostasis is a major survival mechanism for cancer. Dual specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) is a key oncogenic kinase that directly activates the transcription factor heat-shock factor 1 (HSF1) and the 26S proteasome. Targeting DYRK2 has proven to be a trac...

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Detalles Bibliográficos
Autores principales:	Tandon, Vasudha, Moreno, Rita, Allmeroth, Kira, Quinn, Jean, Wiley, Sandra E., Nicely, Lynden G., Denzel, Martin S., Edwards, Joanne, de la Vega, Laureano, Banerjee, Sourav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2023
Materias:	Cancer
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894012/ https://www.ncbi.nlm.nih.gov/pubmed/36622366 http://dx.doi.org/10.1042/BSR20222102

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