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CCAR2 functions downstream of the Shieldin complex to promote double-strand break end-joining

The 53BP1-RIF1 pathway restricts the resection of DNA double-strand breaks (DSBs) and promotes blunt end-ligation by non-homologous end joining (NHEJ) repair. The Shieldin complex is a downstream effector of the 53BP1-RIF1 pathway. Here, we identify a component of this pathway, CCAR2/DBC1, which is...

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Detalles Bibliográficos
Autores principales:	Iyer, Divya Ramalingam, Harada, Naoya, Clairmont, Connor, Jiang, Lige, Martignetti, David, Nguyen, Huy, He, Yizhou Joseph, Chowdhury, Dipanjan, D’Andrea, Alan D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894118/ https://www.ncbi.nlm.nih.gov/pubmed/36442094 http://dx.doi.org/10.1073/pnas.2214935119

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