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SV40 T-antigen uses a DNA shearing mechanism to initiate origin unwinding

Duplication of DNA genomes requires unwinding of the double-strand (ds) DNA so that each single strand (ss) can be copied by a DNA polymerase. The genomes of eukaryotic cells are unwound by two ring-shaped hexameric helicases that initially encircle dsDNA but transition to ssDNA for function as repl...

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Detalles Bibliográficos
Autores principales:	Langston, Lance D., Yuan, Zuanning, Georgescu, Roxana, Li, Huilin, O’Donnell, Michael E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894130/ https://www.ncbi.nlm.nih.gov/pubmed/36442086 http://dx.doi.org/10.1073/pnas.2216240119

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