Cargando…

DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer

SF3B1 is the most frequently mutated spliceosomal gene in cancer. Several hotspot mutations are known to disrupt the interaction of SF3B1 with another splicing factor, SUGP1, resulting in the RNA missplicing that characterizes mutant SF3B1 cancers. Properties of SUGP1, especially the presence of a G...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Jian, Huang, Ji, Xu, Ke, Xing, Peiqi, Huang, Yue, Liu, Zhaoqi, Tong, Liang, Manley, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894173/
https://www.ncbi.nlm.nih.gov/pubmed/36459648
http://dx.doi.org/10.1073/pnas.2216712119