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Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXRα heterodimer

Orphan nuclear receptor Nurr1 plays important roles in the progression of various diseases, including Parkinson’s disease, neuroinflammation, Alzheimer’s disease, and multiple sclerosis. It can recognize DNA as a monomer or heterodimer with retinoid X receptor α (RXRα). But the molecular mechanism o...

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Detalles Bibliográficos
Autores principales:	Zhao, Mohan, Wang, Na, Guo, Yaoting, Li, Jingwen, Yin, Yue, Dong, Yan, Zhu, Jiabin, Peng, Chao, Xu, Tingting, Liu, Jinsong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894219/ https://www.ncbi.nlm.nih.gov/pubmed/36442107 http://dx.doi.org/10.1073/pnas.2206737119

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