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Tumor-targeted delivery of a STING agonist improves cancer immunotherapy

The cGAS-STING pathway is essential for immune defense against microbial pathogens and malignant cells; as such, STING is an attractive target for cancer immunotherapy. However, systemic administration of STING agonists poses safety issues while intratumoral injection is limited by tumor accessibili...

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Detalles Bibliográficos
Autores principales:	Wu, You-tong, Fang, Yan, Wei, Qi, Shi, Heping, Tan, Huiling, Deng, Yafang, Zeng, Zhiqun, Qiu, Jian, Chen, Chuo, Sun, Lijun, Chen, Zhijian J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894229/ https://www.ncbi.nlm.nih.gov/pubmed/36442099 http://dx.doi.org/10.1073/pnas.2214278119

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