High-throughput functional annotation of natural products by integrated activity profiling

Determining mechanism of action (MOA) is one of the biggest challenges in natural products discovery. Here, we report a comprehensive platform that uses Similarity Network Fusion (SNF) to improve MOA predictions by integrating data from the cytological profiling high-content imaging platform and the...

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Detalles Bibliográficos
Autores principales: Hight, Suzie K., Clark, Trevor N., Kurita, Kenji L., McMillan, Elizabeth A., Bray, Walter, Shaikh, Anam F., Khadilkar, Aswad, Haeckl, F. P. Jake, Carnevale-Neto, Fausto, La, Scott, Lohith, Akshar, Vaden, Rachel M., Lee, Jeon, Wei, Shuguang, Lokey, R. Scott, White, Michael A., Linington, Roger G., MacMillan, John B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894231/
https://www.ncbi.nlm.nih.gov/pubmed/36449542
http://dx.doi.org/10.1073/pnas.2208458119

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