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Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer’s disease

Impairments in neural lysosomal- and autophagic-mediated degradation of cellular debris contribute to neuritic dystrophy and synaptic loss. While these are well-characterized features of neurodegenerative disorders such as Alzheimer’s disease (AD), the upstream cellular processes driving deficits in...

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Detalles Bibliográficos
Autores principales:	Mustaly-Kalimi, Sarah, Gallegos, Wacey, Marr, Robert A., Gilman-Sachs, Alice, Peterson, Daniel A., Sekler, Israel, Stutzmann, Grace E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894236/ https://www.ncbi.nlm.nih.gov/pubmed/36442130 http://dx.doi.org/10.1073/pnas.2211999119

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