Impact of Ultra High-risk Genetics on Real-world Outcomes of Transplant-eligible Multiple Myeloma Patients

Refined prediction of early relapse following standard-of-care (SoC) autologous stem cell transplant (ASCT) in newly diagnosed multiple myeloma (NDMM) could inform real-world risk-stratified post-ASCT strategies. We investigated the impact of double hit genetics (≥2 adverse markers: t(4;14), t(14;16...

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Autores principales: Panopoulou, Aikaterini, Easdale, Sandra, Ethell, Mark, Nicholson, Emma, Potter, Mike, Giotas, Asterios, Woods, Helena, Thornton, Tracy, Pawlyn, Charlotte, Boyd, Kevin D., Kaiser, Martin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894354/
https://www.ncbi.nlm.nih.gov/pubmed/36751511
http://dx.doi.org/10.1097/HS9.0000000000000831
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author Panopoulou, Aikaterini
Easdale, Sandra
Ethell, Mark
Nicholson, Emma
Potter, Mike
Giotas, Asterios
Woods, Helena
Thornton, Tracy
Pawlyn, Charlotte
Boyd, Kevin D.
Kaiser, Martin F.
author_facet Panopoulou, Aikaterini
Easdale, Sandra
Ethell, Mark
Nicholson, Emma
Potter, Mike
Giotas, Asterios
Woods, Helena
Thornton, Tracy
Pawlyn, Charlotte
Boyd, Kevin D.
Kaiser, Martin F.
author_sort Panopoulou, Aikaterini
collection PubMed
description Refined prediction of early relapse following standard-of-care (SoC) autologous stem cell transplant (ASCT) in newly diagnosed multiple myeloma (NDMM) could inform real-world risk-stratified post-ASCT strategies. We investigated the impact of double hit genetics (≥2 adverse markers: t(4;14), t(14;16), t(14;20), gain(1q), del(17p)) on outcome in 139 NDMM patients who underwent SoC ASCT between January 2014 and October 2019 at our center. Double hit genetics were associated with a significantly shortened progression-free survival (hazard ratio [HR] = 4.27, P < 0.001) and overall survival (HR = 4.01, P = 0.03), and characterized most early relapses. Our results support the real-world utility of extended genetic profiling for improved risk prediction in NDMM.
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spelling pubmed-98943542023-02-06 Impact of Ultra High-risk Genetics on Real-world Outcomes of Transplant-eligible Multiple Myeloma Patients Panopoulou, Aikaterini Easdale, Sandra Ethell, Mark Nicholson, Emma Potter, Mike Giotas, Asterios Woods, Helena Thornton, Tracy Pawlyn, Charlotte Boyd, Kevin D. Kaiser, Martin F. Hemasphere Article Refined prediction of early relapse following standard-of-care (SoC) autologous stem cell transplant (ASCT) in newly diagnosed multiple myeloma (NDMM) could inform real-world risk-stratified post-ASCT strategies. We investigated the impact of double hit genetics (≥2 adverse markers: t(4;14), t(14;16), t(14;20), gain(1q), del(17p)) on outcome in 139 NDMM patients who underwent SoC ASCT between January 2014 and October 2019 at our center. Double hit genetics were associated with a significantly shortened progression-free survival (hazard ratio [HR] = 4.27, P < 0.001) and overall survival (HR = 4.01, P = 0.03), and characterized most early relapses. Our results support the real-world utility of extended genetic profiling for improved risk prediction in NDMM. Lippincott Williams & Wilkins 2023-01-25 /pmc/articles/PMC9894354/ /pubmed/36751511 http://dx.doi.org/10.1097/HS9.0000000000000831 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Panopoulou, Aikaterini
Easdale, Sandra
Ethell, Mark
Nicholson, Emma
Potter, Mike
Giotas, Asterios
Woods, Helena
Thornton, Tracy
Pawlyn, Charlotte
Boyd, Kevin D.
Kaiser, Martin F.
Impact of Ultra High-risk Genetics on Real-world Outcomes of Transplant-eligible Multiple Myeloma Patients
title Impact of Ultra High-risk Genetics on Real-world Outcomes of Transplant-eligible Multiple Myeloma Patients
title_full Impact of Ultra High-risk Genetics on Real-world Outcomes of Transplant-eligible Multiple Myeloma Patients
title_fullStr Impact of Ultra High-risk Genetics on Real-world Outcomes of Transplant-eligible Multiple Myeloma Patients
title_full_unstemmed Impact of Ultra High-risk Genetics on Real-world Outcomes of Transplant-eligible Multiple Myeloma Patients
title_short Impact of Ultra High-risk Genetics on Real-world Outcomes of Transplant-eligible Multiple Myeloma Patients
title_sort impact of ultra high-risk genetics on real-world outcomes of transplant-eligible multiple myeloma patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894354/
https://www.ncbi.nlm.nih.gov/pubmed/36751511
http://dx.doi.org/10.1097/HS9.0000000000000831
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