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High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury

Chronic kidney disease (CKD) is a worldwide health burden with increases risk of end-stage renal function if left untreated. CKD induced in the context of metabolic syndrome (MS) increases risks of hypertension, hyperglycemia, excess body fat and dyslipidemia. To test if combining a high-fat diet (H...

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Autores principales: Cheff, Véronique, Trentin-Sonoda, Mayra, Blais, Amélie, Thibodeau, Jean-François, Holterman, Chet E., Gutsol, Alex, Kennedy, Christopher R. J., Hébert, Richard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894391/
https://www.ncbi.nlm.nih.gov/pubmed/36730247
http://dx.doi.org/10.1371/journal.pone.0281123
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author Cheff, Véronique
Trentin-Sonoda, Mayra
Blais, Amélie
Thibodeau, Jean-François
Holterman, Chet E.
Gutsol, Alex
Kennedy, Christopher R. J.
Hébert, Richard L.
author_facet Cheff, Véronique
Trentin-Sonoda, Mayra
Blais, Amélie
Thibodeau, Jean-François
Holterman, Chet E.
Gutsol, Alex
Kennedy, Christopher R. J.
Hébert, Richard L.
author_sort Cheff, Véronique
collection PubMed
description Chronic kidney disease (CKD) is a worldwide health burden with increases risk of end-stage renal function if left untreated. CKD induced in the context of metabolic syndrome (MS) increases risks of hypertension, hyperglycemia, excess body fat and dyslipidemia. To test if combining a high-fat diet (HFD) regimen onto the hypertensive/ diabetic phenotype would mimic features of MS induced-CKD in mice, hyperglycemia was induced in genetically hypertensive mice (Lin), followed by HFD regimen. For that, 8-week-old male were subjected to streptozotocin (STZ) intraperitoneal (i.p.) injections (50 mg/kg, 5 days consecutive). LinSTZ were fed a 60% kCal HFD for 8 weeks. Lin mice treated with STZ developed polydipsia, became hypertensive and hyperglycemic. HFD induced weight gain, protected against glomerular hypertrophy, scarring, and albuminuria at endpoint compared to regular diet fed LinSTZ. On the other hand, HFD induced steatosis, liver fibrosis, inflammation, and increase in AST/ALT ratio, characteristics of non-alcoholic liver disease. Taken together, our results show that LinSTZ mice fed a HFD did not lead to a more robust model of MS-induced CKD, protected against kidney injury, but inducing liver damage. More studies are necessary to understand the kidney protective mechanisms of HFD when superimposed with hypertension and type 1 diabetes.
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spelling pubmed-98943912023-02-03 High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury Cheff, Véronique Trentin-Sonoda, Mayra Blais, Amélie Thibodeau, Jean-François Holterman, Chet E. Gutsol, Alex Kennedy, Christopher R. J. Hébert, Richard L. PLoS One Research Article Chronic kidney disease (CKD) is a worldwide health burden with increases risk of end-stage renal function if left untreated. CKD induced in the context of metabolic syndrome (MS) increases risks of hypertension, hyperglycemia, excess body fat and dyslipidemia. To test if combining a high-fat diet (HFD) regimen onto the hypertensive/ diabetic phenotype would mimic features of MS induced-CKD in mice, hyperglycemia was induced in genetically hypertensive mice (Lin), followed by HFD regimen. For that, 8-week-old male were subjected to streptozotocin (STZ) intraperitoneal (i.p.) injections (50 mg/kg, 5 days consecutive). LinSTZ were fed a 60% kCal HFD for 8 weeks. Lin mice treated with STZ developed polydipsia, became hypertensive and hyperglycemic. HFD induced weight gain, protected against glomerular hypertrophy, scarring, and albuminuria at endpoint compared to regular diet fed LinSTZ. On the other hand, HFD induced steatosis, liver fibrosis, inflammation, and increase in AST/ALT ratio, characteristics of non-alcoholic liver disease. Taken together, our results show that LinSTZ mice fed a HFD did not lead to a more robust model of MS-induced CKD, protected against kidney injury, but inducing liver damage. More studies are necessary to understand the kidney protective mechanisms of HFD when superimposed with hypertension and type 1 diabetes. Public Library of Science 2023-02-02 /pmc/articles/PMC9894391/ /pubmed/36730247 http://dx.doi.org/10.1371/journal.pone.0281123 Text en © 2023 Cheff et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Cheff, Véronique
Trentin-Sonoda, Mayra
Blais, Amélie
Thibodeau, Jean-François
Holterman, Chet E.
Gutsol, Alex
Kennedy, Christopher R. J.
Hébert, Richard L.
High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury
title High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury
title_full High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury
title_fullStr High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury
title_full_unstemmed High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury
title_short High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury
title_sort high fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894391/
https://www.ncbi.nlm.nih.gov/pubmed/36730247
http://dx.doi.org/10.1371/journal.pone.0281123
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