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High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury
Chronic kidney disease (CKD) is a worldwide health burden with increases risk of end-stage renal function if left untreated. CKD induced in the context of metabolic syndrome (MS) increases risks of hypertension, hyperglycemia, excess body fat and dyslipidemia. To test if combining a high-fat diet (H...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894391/ https://www.ncbi.nlm.nih.gov/pubmed/36730247 http://dx.doi.org/10.1371/journal.pone.0281123 |
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author | Cheff, Véronique Trentin-Sonoda, Mayra Blais, Amélie Thibodeau, Jean-François Holterman, Chet E. Gutsol, Alex Kennedy, Christopher R. J. Hébert, Richard L. |
author_facet | Cheff, Véronique Trentin-Sonoda, Mayra Blais, Amélie Thibodeau, Jean-François Holterman, Chet E. Gutsol, Alex Kennedy, Christopher R. J. Hébert, Richard L. |
author_sort | Cheff, Véronique |
collection | PubMed |
description | Chronic kidney disease (CKD) is a worldwide health burden with increases risk of end-stage renal function if left untreated. CKD induced in the context of metabolic syndrome (MS) increases risks of hypertension, hyperglycemia, excess body fat and dyslipidemia. To test if combining a high-fat diet (HFD) regimen onto the hypertensive/ diabetic phenotype would mimic features of MS induced-CKD in mice, hyperglycemia was induced in genetically hypertensive mice (Lin), followed by HFD regimen. For that, 8-week-old male were subjected to streptozotocin (STZ) intraperitoneal (i.p.) injections (50 mg/kg, 5 days consecutive). LinSTZ were fed a 60% kCal HFD for 8 weeks. Lin mice treated with STZ developed polydipsia, became hypertensive and hyperglycemic. HFD induced weight gain, protected against glomerular hypertrophy, scarring, and albuminuria at endpoint compared to regular diet fed LinSTZ. On the other hand, HFD induced steatosis, liver fibrosis, inflammation, and increase in AST/ALT ratio, characteristics of non-alcoholic liver disease. Taken together, our results show that LinSTZ mice fed a HFD did not lead to a more robust model of MS-induced CKD, protected against kidney injury, but inducing liver damage. More studies are necessary to understand the kidney protective mechanisms of HFD when superimposed with hypertension and type 1 diabetes. |
format | Online Article Text |
id | pubmed-9894391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-98943912023-02-03 High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury Cheff, Véronique Trentin-Sonoda, Mayra Blais, Amélie Thibodeau, Jean-François Holterman, Chet E. Gutsol, Alex Kennedy, Christopher R. J. Hébert, Richard L. PLoS One Research Article Chronic kidney disease (CKD) is a worldwide health burden with increases risk of end-stage renal function if left untreated. CKD induced in the context of metabolic syndrome (MS) increases risks of hypertension, hyperglycemia, excess body fat and dyslipidemia. To test if combining a high-fat diet (HFD) regimen onto the hypertensive/ diabetic phenotype would mimic features of MS induced-CKD in mice, hyperglycemia was induced in genetically hypertensive mice (Lin), followed by HFD regimen. For that, 8-week-old male were subjected to streptozotocin (STZ) intraperitoneal (i.p.) injections (50 mg/kg, 5 days consecutive). LinSTZ were fed a 60% kCal HFD for 8 weeks. Lin mice treated with STZ developed polydipsia, became hypertensive and hyperglycemic. HFD induced weight gain, protected against glomerular hypertrophy, scarring, and albuminuria at endpoint compared to regular diet fed LinSTZ. On the other hand, HFD induced steatosis, liver fibrosis, inflammation, and increase in AST/ALT ratio, characteristics of non-alcoholic liver disease. Taken together, our results show that LinSTZ mice fed a HFD did not lead to a more robust model of MS-induced CKD, protected against kidney injury, but inducing liver damage. More studies are necessary to understand the kidney protective mechanisms of HFD when superimposed with hypertension and type 1 diabetes. Public Library of Science 2023-02-02 /pmc/articles/PMC9894391/ /pubmed/36730247 http://dx.doi.org/10.1371/journal.pone.0281123 Text en © 2023 Cheff et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Cheff, Véronique Trentin-Sonoda, Mayra Blais, Amélie Thibodeau, Jean-François Holterman, Chet E. Gutsol, Alex Kennedy, Christopher R. J. Hébert, Richard L. High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury |
title | High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury |
title_full | High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury |
title_fullStr | High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury |
title_full_unstemmed | High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury |
title_short | High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury |
title_sort | high fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894391/ https://www.ncbi.nlm.nih.gov/pubmed/36730247 http://dx.doi.org/10.1371/journal.pone.0281123 |
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