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Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study

BACKGROUND: Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA(1C)) in a n...

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Autor principal: Bekkelund, Svein Ivar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894408/
https://www.ncbi.nlm.nih.gov/pubmed/36730257
http://dx.doi.org/10.1371/journal.pone.0281239
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author Bekkelund, Svein Ivar
author_facet Bekkelund, Svein Ivar
author_sort Bekkelund, Svein Ivar
collection PubMed
description BACKGROUND: Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA(1C)) in a nondiabetic general population. METHODS: Associations between CK and the outcome variable HbA(1C) (%) were performed by variance and multivariate analyses in 11662 nondiabetic subjects defined as HbA(1C) (%) <6.5 who participated in the population based Tromsø study (Tromsø 6) in Norway. RESULTS: Abnormal elevated CK was detected in 543/11662 participants (4.66%). Mean HbA(1C) (%) in the “high CK” group was 5.62 (SD = 0.33) compared to 5.52 (SD = 0.36) in the “normal CK” group, P <0.001. CK increased significantly and linearly with higher levels of HbA(1C) (%) quartiles in women (P <0.001) and non-linearly in men (P <0.001). In a multivariate analysis, CK was independently associated with HbA(1C) (%) after adjusting for age, sex, body mass index, blood pressure, glucose, lipids, C-reactive protein, creatinine, alanine transaminase and aspartate aminotransferase. A 1-unit increase in log CK was associated with a 0.17-unit increase in HbA(1C) (%). CONCLUSION: These data demonstrate a positive and independent association between CK and glycated haemoglobin in a nondiabetic general population.
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spelling pubmed-98944082023-02-03 Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study Bekkelund, Svein Ivar PLoS One Research Article BACKGROUND: Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA(1C)) in a nondiabetic general population. METHODS: Associations between CK and the outcome variable HbA(1C) (%) were performed by variance and multivariate analyses in 11662 nondiabetic subjects defined as HbA(1C) (%) <6.5 who participated in the population based Tromsø study (Tromsø 6) in Norway. RESULTS: Abnormal elevated CK was detected in 543/11662 participants (4.66%). Mean HbA(1C) (%) in the “high CK” group was 5.62 (SD = 0.33) compared to 5.52 (SD = 0.36) in the “normal CK” group, P <0.001. CK increased significantly and linearly with higher levels of HbA(1C) (%) quartiles in women (P <0.001) and non-linearly in men (P <0.001). In a multivariate analysis, CK was independently associated with HbA(1C) (%) after adjusting for age, sex, body mass index, blood pressure, glucose, lipids, C-reactive protein, creatinine, alanine transaminase and aspartate aminotransferase. A 1-unit increase in log CK was associated with a 0.17-unit increase in HbA(1C) (%). CONCLUSION: These data demonstrate a positive and independent association between CK and glycated haemoglobin in a nondiabetic general population. Public Library of Science 2023-02-02 /pmc/articles/PMC9894408/ /pubmed/36730257 http://dx.doi.org/10.1371/journal.pone.0281239 Text en © 2023 Svein Ivar Bekkelund https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bekkelund, Svein Ivar
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study
title Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study
title_full Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study
title_fullStr Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study
title_full_unstemmed Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study
title_short Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study
title_sort creatine kinase is associated with glycated haemoglobin in a nondiabetic population. the tromsø study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894408/
https://www.ncbi.nlm.nih.gov/pubmed/36730257
http://dx.doi.org/10.1371/journal.pone.0281239
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