Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in SF3B1-Mutant Myelodysplastic Syndromes With Ringed Sideroblasts

SF3B1 mutations, which occur in 20% of patients with myelodysplastic syndromes (MDS), are the hallmarks of a specific MDS subtype, MDS with ringed sideroblasts (MDS-RS), which is characterized by the accumulation of erythroid precursors in the bone marrow and primarily affects the elderly population...

Descripción completa

Detalles Bibliográficos
Autores principales: Adema, Vera, Ma, Feiyang, Kanagal-Shamanna, Rashmi, Thongon, Natthakan, Montalban-Bravo, Guillermo, Yang, Hui, Peslak, Scott A., Wang, Feng, Acha, Pamela, Sole, Francesc, Lockyer, Pamela, Cassari, Margherita, Maciejewski, Jaroslaw P., Visconte, Valeria, Gañán-Gómez, Irene, Song, Yuanbin, Bueso-Ramos, Carlos, Pellegrini, Matteo, Tan, Tuyet M., Bejar, Rafael, Carew, Jennifer S., Halene, Stephanie, Santini, Valeria, Al-Atrash, Gheath, Clise-Dwyer, Karen, Garcia-Manero, Guillermo, Blobel, Gerd A., Colla, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894566/
https://www.ncbi.nlm.nih.gov/pubmed/35926182
http://dx.doi.org/10.1158/2643-3230.BCD-21-0220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894566/
https://www.ncbi.nlm.nih.gov/pubmed/35926182
http://dx.doi.org/10.1158/2643-3230.BCD-21-0220

Ejemplares similares