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Epidemiology of healthcare-associated SARS-CoV-2 outbreaks in Germany between March 2020 and May 2022

BACKGROUND: Outbreaks in healthcare facilities played a pivotal role in the course of the coronavirus (COVID-19) pandemic. AIM: To investigate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in hospitals, outpatient care, and rehabilitation facilities in Germany from March 202...

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Autores principales: Suwono, B., Brandl, M., Hecht, J., Eckmanns, T., Haller, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Healthcare Infection Society. Published by Elsevier Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894679/
https://www.ncbi.nlm.nih.gov/pubmed/36738991
http://dx.doi.org/10.1016/j.jhin.2023.01.011
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author Suwono, B.
Brandl, M.
Hecht, J.
Eckmanns, T.
Haller, S.
author_facet Suwono, B.
Brandl, M.
Hecht, J.
Eckmanns, T.
Haller, S.
author_sort Suwono, B.
collection PubMed
description BACKGROUND: Outbreaks in healthcare facilities played a pivotal role in the course of the coronavirus (COVID-19) pandemic. AIM: To investigate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in hospitals, outpatient care, and rehabilitation facilities in Germany from March 2020 to May 2022. METHODS: Data from the German mandatory notification system were used to describe outbreaks by number of cases and case fatality ratio (CFR), and outbreak cases by age and gender. Using Pearson correlation, the dynamics of cases in the general population were compared with cases in healthcare-associated infection (HAI) SARS-CoV-2 outbreaks before and after the start of the vaccination campaign. Additionally, a counterfactual scenario was used to estimate numbers of prevented HAI cases, using the phase before vaccination as baseline. FINDINGS: By the end of May 2022, 8941 healthcare-associated outbreaks were observed with 73,626 cases: 51,504 in hospitals, 15,524 in outpatient care, and 6598 in rehabilitation facilities. Median number of cases per outbreak was 4 (range: 2–342) and cases were more frequently reported in women with 46,818 (63.6%). Overall CFR was 8.1%, higher in men (12.4%) than in women (5.7%). After the vaccination campaign was fully introduced, the association between increasing incidence in the general population and consecutive outbreak cases was decreased by a factor of 10. Furthermore, our counterfactual analysis suggests that more than 55,000 outbreak cases could have been prevented until the end of 2021. CONCLUSION: The vaccination campaign in combination with non-pharmaceutical measures was key to reduce number, size and CFR of healthcare-associated outbreaks.
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spelling pubmed-98946792023-02-06 Epidemiology of healthcare-associated SARS-CoV-2 outbreaks in Germany between March 2020 and May 2022 Suwono, B. Brandl, M. Hecht, J. Eckmanns, T. Haller, S. J Hosp Infect Article BACKGROUND: Outbreaks in healthcare facilities played a pivotal role in the course of the coronavirus (COVID-19) pandemic. AIM: To investigate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in hospitals, outpatient care, and rehabilitation facilities in Germany from March 2020 to May 2022. METHODS: Data from the German mandatory notification system were used to describe outbreaks by number of cases and case fatality ratio (CFR), and outbreak cases by age and gender. Using Pearson correlation, the dynamics of cases in the general population were compared with cases in healthcare-associated infection (HAI) SARS-CoV-2 outbreaks before and after the start of the vaccination campaign. Additionally, a counterfactual scenario was used to estimate numbers of prevented HAI cases, using the phase before vaccination as baseline. FINDINGS: By the end of May 2022, 8941 healthcare-associated outbreaks were observed with 73,626 cases: 51,504 in hospitals, 15,524 in outpatient care, and 6598 in rehabilitation facilities. Median number of cases per outbreak was 4 (range: 2–342) and cases were more frequently reported in women with 46,818 (63.6%). Overall CFR was 8.1%, higher in men (12.4%) than in women (5.7%). After the vaccination campaign was fully introduced, the association between increasing incidence in the general population and consecutive outbreak cases was decreased by a factor of 10. Furthermore, our counterfactual analysis suggests that more than 55,000 outbreak cases could have been prevented until the end of 2021. CONCLUSION: The vaccination campaign in combination with non-pharmaceutical measures was key to reduce number, size and CFR of healthcare-associated outbreaks. The Healthcare Infection Society. Published by Elsevier Ltd. 2023-04 2023-02-03 /pmc/articles/PMC9894679/ /pubmed/36738991 http://dx.doi.org/10.1016/j.jhin.2023.01.011 Text en © 2023 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Suwono, B.
Brandl, M.
Hecht, J.
Eckmanns, T.
Haller, S.
Epidemiology of healthcare-associated SARS-CoV-2 outbreaks in Germany between March 2020 and May 2022
title Epidemiology of healthcare-associated SARS-CoV-2 outbreaks in Germany between March 2020 and May 2022
title_full Epidemiology of healthcare-associated SARS-CoV-2 outbreaks in Germany between March 2020 and May 2022
title_fullStr Epidemiology of healthcare-associated SARS-CoV-2 outbreaks in Germany between March 2020 and May 2022
title_full_unstemmed Epidemiology of healthcare-associated SARS-CoV-2 outbreaks in Germany between March 2020 and May 2022
title_short Epidemiology of healthcare-associated SARS-CoV-2 outbreaks in Germany between March 2020 and May 2022
title_sort epidemiology of healthcare-associated sars-cov-2 outbreaks in germany between march 2020 and may 2022
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894679/
https://www.ncbi.nlm.nih.gov/pubmed/36738991
http://dx.doi.org/10.1016/j.jhin.2023.01.011
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