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Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei

Micronuclei (MN) are cytosolic bodies that sequester acentric fragments or mis-segregated chromosomes from the primary nucleus. Spontaneous rupture of the MN envelope allows recognition by the viral receptor cyclic GMP-AMP synthase (cGAS), initiating interferon signaling downstream of DNA damage. He...

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Detalles Bibliográficos
Autores principales:	MacDonald, Kate M., Nicholson-Puthenveedu, Shirony, Tageldein, Maha M., Khasnis, Sarika, Arrowsmith, Cheryl H., Harding, Shane M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894866/ https://www.ncbi.nlm.nih.gov/pubmed/36732527 http://dx.doi.org/10.1038/s41467-023-36195-8

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