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Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury

NADPH oxidases (NOX's), and the reactive oxygen species (ROS) they produce, play an important role in host defense, thyroid hormone synthesis, apoptosis, gene regulation, angiogenesis and other processes. However, overproduction of ROS by these enzymes is associated with cardiovascular disease,...

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Detalles Bibliográficos
Autores principales: Mason, Hannah, Rai, Ganesha, Kozyr, Arina, De Jonge, Nathaniel, Gliniewicz, Emily, Berg, Lars J., Wald, Gal, Dorrier, Cayce, Henderson, Mark J., Zakharov, Alexey, Dyson, Tristan, Audley, John, Pettinato, Anthony M., Padilha, Elias Carvalho, Shah, Pranav, Xu, Xin, Leto, Thomas L., Simeonov, Anton, Zarember, Kol A., McGavern, Dorian B., Gallin, John I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894920/
https://www.ncbi.nlm.nih.gov/pubmed/36709665
http://dx.doi.org/10.1016/j.redox.2023.102611