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Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury
NADPH oxidases (NOX's), and the reactive oxygen species (ROS) they produce, play an important role in host defense, thyroid hormone synthesis, apoptosis, gene regulation, angiogenesis and other processes. However, overproduction of ROS by these enzymes is associated with cardiovascular disease,...
Autores principales: | Mason, Hannah, Rai, Ganesha, Kozyr, Arina, De Jonge, Nathaniel, Gliniewicz, Emily, Berg, Lars J., Wald, Gal, Dorrier, Cayce, Henderson, Mark J., Zakharov, Alexey, Dyson, Tristan, Audley, John, Pettinato, Anthony M., Padilha, Elias Carvalho, Shah, Pranav, Xu, Xin, Leto, Thomas L., Simeonov, Anton, Zarember, Kol A., McGavern, Dorian B., Gallin, John I. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894920/ https://www.ncbi.nlm.nih.gov/pubmed/36709665 http://dx.doi.org/10.1016/j.redox.2023.102611 |
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