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The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
Amyloid-like aggregates of the microtubule-associated protein Tau are associated with several neurodegenerative disorders including Alzheimer’s disease. The existence of cellular machinery for the removal of such aggregates has remained unclear, as specialized disaggregase chaperones are thought to...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894937/ https://www.ncbi.nlm.nih.gov/pubmed/36732333 http://dx.doi.org/10.1038/s41467-023-36058-2 |