Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence

Pel exopolysaccharide biosynthetic loci are phylogenetically widespread biofilm matrix determinants in bacteria. In Pseudomonas aeruginosa, Pel is crucial for cell-to-cell interactions and reducing susceptibility to antibiotic and mucolytic treatments. While genes encoding glycoside hydrolases have...

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Detalles Bibliográficos
Autores principales: Razvi, Erum, Whitfield, Gregory B., Reichhardt, Courtney, Dreifus, Julia E., Willis, Alexandra R., Gluscencova, Oxana B., Gloag, Erin S., Awad, Tarek S., Rich, Jacquelyn D., da Silva, Daniel Passos, Bond, Whitney, Le Mauff, François, Sheppard, Donald C., Hatton, Benjamin D., Stoodley, Paul, Reinke, Aaron W., Boulianne, Gabrielle L., Wozniak, Daniel J., Harrison, Joe J., Parsek, Matthew R., Howell, P. Lynne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894940/
https://www.ncbi.nlm.nih.gov/pubmed/36732330
http://dx.doi.org/10.1038/s41522-023-00375-7

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