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Partial body cryotherapy exposure drives acute redistribution of circulating lymphocytes: preliminary findings

Partial body cryotherapy (PBC) is proposed to alleviate symptoms of exercise-induced muscle damage (EIMD) by reducing associated inflammation. No studies have assessed acute PBC exposure on peripheral blood mononuclear cell mobilisation or compared these with cold water immersion (CWI), which may in...

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Autores principales: Rose, Catriona L., McGuire, Helen, Graham, Kenneth, Siegler, Jason, de St Groth, Barbara Fazekas, Caillaud, Corinne, Edwards, Kate M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894947/
https://www.ncbi.nlm.nih.gov/pubmed/36348102
http://dx.doi.org/10.1007/s00421-022-05058-3
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author Rose, Catriona L.
McGuire, Helen
Graham, Kenneth
Siegler, Jason
de St Groth, Barbara Fazekas
Caillaud, Corinne
Edwards, Kate M.
author_facet Rose, Catriona L.
McGuire, Helen
Graham, Kenneth
Siegler, Jason
de St Groth, Barbara Fazekas
Caillaud, Corinne
Edwards, Kate M.
author_sort Rose, Catriona L.
collection PubMed
description Partial body cryotherapy (PBC) is proposed to alleviate symptoms of exercise-induced muscle damage (EIMD) by reducing associated inflammation. No studies have assessed acute PBC exposure on peripheral blood mononuclear cell mobilisation or compared these with cold water immersion (CWI), which may inform how PBC impacts inflammatory processes. This trial examined the impact of a single PBC exposure on circulating peripheral blood mononuclear cells compared to CWI or a control. 26 males were randomised into either PBC (3 min at − 110 to − 140 °C), CWI (3 min at 9 °C), or control (3 min at 24 °C), with blood samples, heart rate, and blood pressure taken before and after exposure. Cytometric analysis determined that CD8(+) T-cell populations were significantly elevated after treatments, with PBC increasing CD8(+) T cells to a greater degree than either CWI or CON. Natural killer cell counts were also elevated after PBC, with the increase attributed specifically to the CD56(lo)CD16(+) cytotoxic subset. This provides the first evidence for the effect of PBC exposure on redistribution of immune cells. An increase in circulating leukocyte subsets such as CD8(+) T cells and CD56(lo)CD16(+) natural killer cells suggests that PBC may induce a transient mobilisation of lymphocytes. PBC may thus enable a more efficient trafficking of these cells from the circulation to the site of initial cellular insult from exercise, potentially accelerating the process of cellular recovery. This provides novel evidence on the use of PBC as a recovery treatment and may also have applicability in other clinical settings involving the recovery of damaged skeletal muscle.
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spelling pubmed-98949472023-02-04 Partial body cryotherapy exposure drives acute redistribution of circulating lymphocytes: preliminary findings Rose, Catriona L. McGuire, Helen Graham, Kenneth Siegler, Jason de St Groth, Barbara Fazekas Caillaud, Corinne Edwards, Kate M. Eur J Appl Physiol Original Article Partial body cryotherapy (PBC) is proposed to alleviate symptoms of exercise-induced muscle damage (EIMD) by reducing associated inflammation. No studies have assessed acute PBC exposure on peripheral blood mononuclear cell mobilisation or compared these with cold water immersion (CWI), which may inform how PBC impacts inflammatory processes. This trial examined the impact of a single PBC exposure on circulating peripheral blood mononuclear cells compared to CWI or a control. 26 males were randomised into either PBC (3 min at − 110 to − 140 °C), CWI (3 min at 9 °C), or control (3 min at 24 °C), with blood samples, heart rate, and blood pressure taken before and after exposure. Cytometric analysis determined that CD8(+) T-cell populations were significantly elevated after treatments, with PBC increasing CD8(+) T cells to a greater degree than either CWI or CON. Natural killer cell counts were also elevated after PBC, with the increase attributed specifically to the CD56(lo)CD16(+) cytotoxic subset. This provides the first evidence for the effect of PBC exposure on redistribution of immune cells. An increase in circulating leukocyte subsets such as CD8(+) T cells and CD56(lo)CD16(+) natural killer cells suggests that PBC may induce a transient mobilisation of lymphocytes. PBC may thus enable a more efficient trafficking of these cells from the circulation to the site of initial cellular insult from exercise, potentially accelerating the process of cellular recovery. This provides novel evidence on the use of PBC as a recovery treatment and may also have applicability in other clinical settings involving the recovery of damaged skeletal muscle. Springer Berlin Heidelberg 2022-11-09 2023 /pmc/articles/PMC9894947/ /pubmed/36348102 http://dx.doi.org/10.1007/s00421-022-05058-3 Text en © The Author(s) 2022, corrected publication https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Rose, Catriona L.
McGuire, Helen
Graham, Kenneth
Siegler, Jason
de St Groth, Barbara Fazekas
Caillaud, Corinne
Edwards, Kate M.
Partial body cryotherapy exposure drives acute redistribution of circulating lymphocytes: preliminary findings
title Partial body cryotherapy exposure drives acute redistribution of circulating lymphocytes: preliminary findings
title_full Partial body cryotherapy exposure drives acute redistribution of circulating lymphocytes: preliminary findings
title_fullStr Partial body cryotherapy exposure drives acute redistribution of circulating lymphocytes: preliminary findings
title_full_unstemmed Partial body cryotherapy exposure drives acute redistribution of circulating lymphocytes: preliminary findings
title_short Partial body cryotherapy exposure drives acute redistribution of circulating lymphocytes: preliminary findings
title_sort partial body cryotherapy exposure drives acute redistribution of circulating lymphocytes: preliminary findings
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894947/
https://www.ncbi.nlm.nih.gov/pubmed/36348102
http://dx.doi.org/10.1007/s00421-022-05058-3
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