Effect of ATG12–ATG5-ATG16L1 autophagy E3-like complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion

In macroautophagy, the autophagosome (AP) engulfs portions of cytoplasm to allow their lysosomal degradation. AP formation in humans requires the concerted action of the ATG12 and LC3/GABARAP conjugation systems. The ATG12–ATG5-ATG16L1 or E3-like complex (E3 for short) acts as a ubiquitin-like E3 en...

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Detalles Bibliográficos
Autores principales: Iriondo, Marina N., Etxaniz, Asier, Varela, Yaiza R., Ballesteros, Uxue, Lázaro, Melisa, Valle, Mikel, Fracchiolla, Dorotea, Martens, Sascha, Montes, L. Ruth, Goñi, Félix M., Alonso, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894987/
https://www.ncbi.nlm.nih.gov/pubmed/36729310
http://dx.doi.org/10.1007/s00018-023-04704-z

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