Loss of 5-hydroxymethylcytosine induces chemotherapy resistance in hepatocellular carcinoma via the 5-hmC/PCAF/AKT axis

Multidrug resistance is a major challenge in treating advanced hepatocellular carcinoma (HCC). Although recent studies have reported that the multidrug resistance phenotype is associated with abnormal DNA methylation in cancer cells, the epigenetic mechanism underlying multidrug resistance remains u...

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Detalles Bibliográficos
Autores principales: Guo, Xiao-Jun, Huang, Xiao-Yong, Yang, Xuan, Lu, Jia-Cheng, Wei, Chuan-Yuan, Gao, Chao, Pei, Yan-Zi, Chen, Yi, Sun, Qi-Man, Cai, Jia-Bin, Zhou, Jian, Fan, Jia, Ke, Ai-Wu, Shi, Yujiang G., Shen, Ying-Hao, Zhang, Peng-Fei, Shi, Guo-Ming, Yang, Guo-Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895048/
https://www.ncbi.nlm.nih.gov/pubmed/36732324
http://dx.doi.org/10.1038/s41419-022-05406-3

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