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Non-canonical functions of spliceosome components in cancer progression

Dysregulation of pre-mRNA splicing is a common hallmark of cancer cells and it is associated with altered expression, localization, and mutations of the components of the splicing machinery. In the last few years, it has been elucidated that spliceosome components can also influence cellular process...

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Autores principales: Ivanova, Olga M., Anufrieva, Ksenia S., Kazakova, Anastasia N., Malyants, Irina K., Shnaider, Polina V., Lukina, Maria M., Shender, Victoria O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895063/
https://www.ncbi.nlm.nih.gov/pubmed/36732501
http://dx.doi.org/10.1038/s41419-022-05470-9
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author Ivanova, Olga M.
Anufrieva, Ksenia S.
Kazakova, Anastasia N.
Malyants, Irina K.
Shnaider, Polina V.
Lukina, Maria M.
Shender, Victoria O.
author_facet Ivanova, Olga M.
Anufrieva, Ksenia S.
Kazakova, Anastasia N.
Malyants, Irina K.
Shnaider, Polina V.
Lukina, Maria M.
Shender, Victoria O.
author_sort Ivanova, Olga M.
collection PubMed
description Dysregulation of pre-mRNA splicing is a common hallmark of cancer cells and it is associated with altered expression, localization, and mutations of the components of the splicing machinery. In the last few years, it has been elucidated that spliceosome components can also influence cellular processes in a splicing-independent manner. Here, we analyze open source data to understand the effect of the knockdown of splicing factors in human cells on the expression and splicing of genes relevant to cell proliferation, migration, cell cycle regulation, DNA repair, and cell death. We supplement this information with a comprehensive literature review of non-canonical functions of splicing factors linked to cancer progression. We also specifically discuss the involvement of splicing factors in intercellular communication and known autoregulatory mechanisms in restoring their levels in cells. Finally, we discuss strategies to target components of the spliceosome machinery that are promising for anticancer therapy. Altogether, this review greatly expands understanding of the role of spliceosome proteins in cancer progression.
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spelling pubmed-98950632023-02-04 Non-canonical functions of spliceosome components in cancer progression Ivanova, Olga M. Anufrieva, Ksenia S. Kazakova, Anastasia N. Malyants, Irina K. Shnaider, Polina V. Lukina, Maria M. Shender, Victoria O. Cell Death Dis Review Article Dysregulation of pre-mRNA splicing is a common hallmark of cancer cells and it is associated with altered expression, localization, and mutations of the components of the splicing machinery. In the last few years, it has been elucidated that spliceosome components can also influence cellular processes in a splicing-independent manner. Here, we analyze open source data to understand the effect of the knockdown of splicing factors in human cells on the expression and splicing of genes relevant to cell proliferation, migration, cell cycle regulation, DNA repair, and cell death. We supplement this information with a comprehensive literature review of non-canonical functions of splicing factors linked to cancer progression. We also specifically discuss the involvement of splicing factors in intercellular communication and known autoregulatory mechanisms in restoring their levels in cells. Finally, we discuss strategies to target components of the spliceosome machinery that are promising for anticancer therapy. Altogether, this review greatly expands understanding of the role of spliceosome proteins in cancer progression. Nature Publishing Group UK 2023-02-02 /pmc/articles/PMC9895063/ /pubmed/36732501 http://dx.doi.org/10.1038/s41419-022-05470-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Ivanova, Olga M.
Anufrieva, Ksenia S.
Kazakova, Anastasia N.
Malyants, Irina K.
Shnaider, Polina V.
Lukina, Maria M.
Shender, Victoria O.
Non-canonical functions of spliceosome components in cancer progression
title Non-canonical functions of spliceosome components in cancer progression
title_full Non-canonical functions of spliceosome components in cancer progression
title_fullStr Non-canonical functions of spliceosome components in cancer progression
title_full_unstemmed Non-canonical functions of spliceosome components in cancer progression
title_short Non-canonical functions of spliceosome components in cancer progression
title_sort non-canonical functions of spliceosome components in cancer progression
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895063/
https://www.ncbi.nlm.nih.gov/pubmed/36732501
http://dx.doi.org/10.1038/s41419-022-05470-9
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