Genome-wide deposition of 6-methyladenine in human DNA reduces the viability of HEK293 cells and directly influences gene expression

While cytosine-C5 methylation of DNA is an essential regulatory system in higher eukaryotes, the presence and relevance of 6-methyladenine (m6dA) in human cells is controversial. To study the role of m6dA in human DNA, we introduced it in human cells at a genome-wide scale at GANTC and GATC sites by...

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Detalles Bibliográficos
Autores principales: Broche, Julian, Köhler, Anja R., Kühnel, Fiona, Osteresch, Bernd, Chandrasekaran, Thyagarajan T., Adam, Sabrina, Brockmeyer, Jens, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895073/
https://www.ncbi.nlm.nih.gov/pubmed/36732350
http://dx.doi.org/10.1038/s42003-023-04466-1

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