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Semen parameters and male reproductive potential are not adversely affected after three or more months of recovery from COVID-19 disease
BACKGROUND: The male reproductive system may be a potential target for SARS-CoV-2 since the presence of ACE and TMPRS2 receptors. After a first report of the presence of SARS-CoV-2 in semen of COVID-19 patients, several papers reported that SARS-CoV-2 was not detected in the semen. However, some evi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895115/ https://www.ncbi.nlm.nih.gov/pubmed/36743823 http://dx.doi.org/10.3389/frph.2022.1114308 |
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author | Stigliani, Sara Massarotti, Claudia Bovis, Francesca Maccarini, Elena Anserini, Paola Scaruffi, Paola |
author_facet | Stigliani, Sara Massarotti, Claudia Bovis, Francesca Maccarini, Elena Anserini, Paola Scaruffi, Paola |
author_sort | Stigliani, Sara |
collection | PubMed |
description | BACKGROUND: The male reproductive system may be a potential target for SARS-CoV-2 since the presence of ACE and TMPRS2 receptors. After a first report of the presence of SARS-CoV-2 in semen of COVID-19 patients, several papers reported that SARS-CoV-2 was not detected in the semen. However, some evidences indicated that COVID-19 disease could impair semen parameters. During the infection, or in a short period after, a reduction in sperm concentration and motility and an increase in DNA fragmentation were observed, even in asymptomatic patients. There is no conclusive data exploring whether this damage changes with time. We investigated whether COVID-19 disease has a negative impact on semen parameters and male reproductive potential after recovery. METHODS: In this longitudinal retrospective study, we enrolled 20 men who had COVID-19 disease. We compared sperm parameters in samples collected before COVID-19 and after infection (8.3 ± 4.8 months). We also evaluated the reproductive potential in pre- and post-COVID-19 infertility treatments of 8 self-controlled couples as well as in 40 cycles after COVID-19 infection of the male partner. RESULTS: For most patients, we obtained results of more than one semen analysis before and after COVID-19. After adjusting for age, days of sexual abstinence, frequency of ejaculations and presence of fever, we found no significant difference over time in any semen parameter. The interval between COVID-19 infection and subsequent infertility treatments was 10.7 ± 7.5 months. There were no differences in the embryological and clinical outcomes of infertility treatments performed before and after male infection. One couple obtained a single pregnancy in the post COVID-19 IUI. Normal fertilization (65%), cleavage (99%) and blastocyst development (40%) rates in treatments performed after male infection were within the expected range of competencies. A total of 5 singleton and 1 twin clinical pregnancies were obtained, and 6 healthy children were born. A total of 10 blastocysts have been cryopreserved. CONCLUSION: Our data are reassuring that COVID-19 disease has no negative effect on semen quality and male reproductive potential when semen samples are collected three months or more after infection. |
format | Online Article Text |
id | pubmed-9895115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98951152023-02-04 Semen parameters and male reproductive potential are not adversely affected after three or more months of recovery from COVID-19 disease Stigliani, Sara Massarotti, Claudia Bovis, Francesca Maccarini, Elena Anserini, Paola Scaruffi, Paola Front Reprod Health Reproductive Health BACKGROUND: The male reproductive system may be a potential target for SARS-CoV-2 since the presence of ACE and TMPRS2 receptors. After a first report of the presence of SARS-CoV-2 in semen of COVID-19 patients, several papers reported that SARS-CoV-2 was not detected in the semen. However, some evidences indicated that COVID-19 disease could impair semen parameters. During the infection, or in a short period after, a reduction in sperm concentration and motility and an increase in DNA fragmentation were observed, even in asymptomatic patients. There is no conclusive data exploring whether this damage changes with time. We investigated whether COVID-19 disease has a negative impact on semen parameters and male reproductive potential after recovery. METHODS: In this longitudinal retrospective study, we enrolled 20 men who had COVID-19 disease. We compared sperm parameters in samples collected before COVID-19 and after infection (8.3 ± 4.8 months). We also evaluated the reproductive potential in pre- and post-COVID-19 infertility treatments of 8 self-controlled couples as well as in 40 cycles after COVID-19 infection of the male partner. RESULTS: For most patients, we obtained results of more than one semen analysis before and after COVID-19. After adjusting for age, days of sexual abstinence, frequency of ejaculations and presence of fever, we found no significant difference over time in any semen parameter. The interval between COVID-19 infection and subsequent infertility treatments was 10.7 ± 7.5 months. There were no differences in the embryological and clinical outcomes of infertility treatments performed before and after male infection. One couple obtained a single pregnancy in the post COVID-19 IUI. Normal fertilization (65%), cleavage (99%) and blastocyst development (40%) rates in treatments performed after male infection were within the expected range of competencies. A total of 5 singleton and 1 twin clinical pregnancies were obtained, and 6 healthy children were born. A total of 10 blastocysts have been cryopreserved. CONCLUSION: Our data are reassuring that COVID-19 disease has no negative effect on semen quality and male reproductive potential when semen samples are collected three months or more after infection. Frontiers Media S.A. 2023-01-20 /pmc/articles/PMC9895115/ /pubmed/36743823 http://dx.doi.org/10.3389/frph.2022.1114308 Text en © 2023 Stigliani, Massarotti, Bovis, Maccarini, Anserini and Scaruffi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Reproductive Health Stigliani, Sara Massarotti, Claudia Bovis, Francesca Maccarini, Elena Anserini, Paola Scaruffi, Paola Semen parameters and male reproductive potential are not adversely affected after three or more months of recovery from COVID-19 disease |
title | Semen parameters and male reproductive potential are not adversely affected after three or more months of recovery from COVID-19 disease |
title_full | Semen parameters and male reproductive potential are not adversely affected after three or more months of recovery from COVID-19 disease |
title_fullStr | Semen parameters and male reproductive potential are not adversely affected after three or more months of recovery from COVID-19 disease |
title_full_unstemmed | Semen parameters and male reproductive potential are not adversely affected after three or more months of recovery from COVID-19 disease |
title_short | Semen parameters and male reproductive potential are not adversely affected after three or more months of recovery from COVID-19 disease |
title_sort | semen parameters and male reproductive potential are not adversely affected after three or more months of recovery from covid-19 disease |
topic | Reproductive Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895115/ https://www.ncbi.nlm.nih.gov/pubmed/36743823 http://dx.doi.org/10.3389/frph.2022.1114308 |
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