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Developmental and functional relationships between hypothalamic tanycytes and embryonic radial glia

The hypothalamus is a key regulator of several homeostatic processes, such as circadian rhythms, energy balance, thirst, and thermoregulation. Recently, the hypothalamic third ventricle has emerged as a site of postnatal neurogenesis and gliogenesis. This hypothalamic neural stem potential resides i...

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Detalles Bibliográficos
Autores principales: Fong, Harmony, Kurrasch, Deborah M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895379/
https://www.ncbi.nlm.nih.gov/pubmed/36741057
http://dx.doi.org/10.3389/fnins.2022.1129414
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author Fong, Harmony
Kurrasch, Deborah M.
author_facet Fong, Harmony
Kurrasch, Deborah M.
author_sort Fong, Harmony
collection PubMed
description The hypothalamus is a key regulator of several homeostatic processes, such as circadian rhythms, energy balance, thirst, and thermoregulation. Recently, the hypothalamic third ventricle has emerged as a site of postnatal neurogenesis and gliogenesis. This hypothalamic neural stem potential resides in a heterogeneous population of cells known as tanycytes, which, not unlike radial glia, line the floor and ventrolateral walls of the third ventricle and extend a long process into the hypothalamic parenchyma. Here, we will review historical and recent data regarding tanycyte biology across the lifespan, focusing on the developmental emergence of these diverse cells from embryonic radial glia and their eventual role contributing to a fascinating, but relatively poorly characterized, adult neural stem cell niche.
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spelling pubmed-98953792023-02-04 Developmental and functional relationships between hypothalamic tanycytes and embryonic radial glia Fong, Harmony Kurrasch, Deborah M. Front Neurosci Neuroscience The hypothalamus is a key regulator of several homeostatic processes, such as circadian rhythms, energy balance, thirst, and thermoregulation. Recently, the hypothalamic third ventricle has emerged as a site of postnatal neurogenesis and gliogenesis. This hypothalamic neural stem potential resides in a heterogeneous population of cells known as tanycytes, which, not unlike radial glia, line the floor and ventrolateral walls of the third ventricle and extend a long process into the hypothalamic parenchyma. Here, we will review historical and recent data regarding tanycyte biology across the lifespan, focusing on the developmental emergence of these diverse cells from embryonic radial glia and their eventual role contributing to a fascinating, but relatively poorly characterized, adult neural stem cell niche. Frontiers Media S.A. 2023-01-20 /pmc/articles/PMC9895379/ /pubmed/36741057 http://dx.doi.org/10.3389/fnins.2022.1129414 Text en Copyright © 2023 Fong and Kurrasch. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Fong, Harmony
Kurrasch, Deborah M.
Developmental and functional relationships between hypothalamic tanycytes and embryonic radial glia
title Developmental and functional relationships between hypothalamic tanycytes and embryonic radial glia
title_full Developmental and functional relationships between hypothalamic tanycytes and embryonic radial glia
title_fullStr Developmental and functional relationships between hypothalamic tanycytes and embryonic radial glia
title_full_unstemmed Developmental and functional relationships between hypothalamic tanycytes and embryonic radial glia
title_short Developmental and functional relationships between hypothalamic tanycytes and embryonic radial glia
title_sort developmental and functional relationships between hypothalamic tanycytes and embryonic radial glia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895379/
https://www.ncbi.nlm.nih.gov/pubmed/36741057
http://dx.doi.org/10.3389/fnins.2022.1129414
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