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Association between growth differentiation factor 15 levels and gestational diabetes mellitus: A combined analysis
OBJECTIVE: Gestational diabetes mellitus (GDM) is a common glucose metabolism disease occurs in pregnancy that affects both maternal and neonatal health. Recently, increasing studies have attached importance to the relationship between growth differentiation factor 15 (GDF-15) and GDM, but the resul...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895392/ https://www.ncbi.nlm.nih.gov/pubmed/36742413 http://dx.doi.org/10.3389/fendo.2023.1084896 |
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author | Lu, Yi-Cheng Liu, Song-Liang Zhang, Yu-Shan Liang, Fei Zhu, Xiao-Yan Xiao, Yue Wang, Jing Ding, Cong Banerjee, Sudipta Yin, Jie-Yun Ma, Qiu-Ping |
author_facet | Lu, Yi-Cheng Liu, Song-Liang Zhang, Yu-Shan Liang, Fei Zhu, Xiao-Yan Xiao, Yue Wang, Jing Ding, Cong Banerjee, Sudipta Yin, Jie-Yun Ma, Qiu-Ping |
author_sort | Lu, Yi-Cheng |
collection | PubMed |
description | OBJECTIVE: Gestational diabetes mellitus (GDM) is a common glucose metabolism disease occurs in pregnancy that affects both maternal and neonatal health. Recently, increasing studies have attached importance to the relationship between growth differentiation factor 15 (GDF-15) and GDM, but the results were inconclusive. Therefore, we conducted a meta-analysis to examine the association between GDF-15 and GDM. MATERIALS AND METHODS: A systematical search was performed in Gene Expression Omnibus (GEO), PubMed and Google Scholar till Oct 27, 2022. We first calculated the mean and standard deviation of GDF-15 expression levels from the included eligible datasets and articles. Then, a meta-analysis was conducted to depict the difference in GDF-15 mRNA or GDF-15 protein expression between case and control groups by using conservative random effect model. Moreover, the potential publication bias was checked with the aid of Begg’s test and Egger’s test. Finally, sensitivity analyses were performed by changing the inclusion criteria. RESULTS: In summary, 12 GEO datasets and 5 articles were enrolled in our study, including 789 GDM patients and 1202 non-GDM pregnant women. It was found that the expression levels of GDF-15 mRNA and GDF-15 protein in late pregnancy were significantly higher in GDM patients compared with non-GDM pregnant women, with the standard mean difference (SMD) and 95% confidence interval (95% CI) of 0.48 (0.14, 0.83) and 0.82 (0.32-1.33), respectively. Meanwhile, a slightly weakened association between GDF-15 protein levels and GDM was also observed in the middle pregnancy, with SMD (95% CI) of 0.53 (0.04-1.02). CONCLUSION: In all, our results suggested that the expression levels of GDF-15 were significantly higher in GDM patients compared with non-GDM pregnant women, especially in the late pregnancy. |
format | Online Article Text |
id | pubmed-9895392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98953922023-02-04 Association between growth differentiation factor 15 levels and gestational diabetes mellitus: A combined analysis Lu, Yi-Cheng Liu, Song-Liang Zhang, Yu-Shan Liang, Fei Zhu, Xiao-Yan Xiao, Yue Wang, Jing Ding, Cong Banerjee, Sudipta Yin, Jie-Yun Ma, Qiu-Ping Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: Gestational diabetes mellitus (GDM) is a common glucose metabolism disease occurs in pregnancy that affects both maternal and neonatal health. Recently, increasing studies have attached importance to the relationship between growth differentiation factor 15 (GDF-15) and GDM, but the results were inconclusive. Therefore, we conducted a meta-analysis to examine the association between GDF-15 and GDM. MATERIALS AND METHODS: A systematical search was performed in Gene Expression Omnibus (GEO), PubMed and Google Scholar till Oct 27, 2022. We first calculated the mean and standard deviation of GDF-15 expression levels from the included eligible datasets and articles. Then, a meta-analysis was conducted to depict the difference in GDF-15 mRNA or GDF-15 protein expression between case and control groups by using conservative random effect model. Moreover, the potential publication bias was checked with the aid of Begg’s test and Egger’s test. Finally, sensitivity analyses were performed by changing the inclusion criteria. RESULTS: In summary, 12 GEO datasets and 5 articles were enrolled in our study, including 789 GDM patients and 1202 non-GDM pregnant women. It was found that the expression levels of GDF-15 mRNA and GDF-15 protein in late pregnancy were significantly higher in GDM patients compared with non-GDM pregnant women, with the standard mean difference (SMD) and 95% confidence interval (95% CI) of 0.48 (0.14, 0.83) and 0.82 (0.32-1.33), respectively. Meanwhile, a slightly weakened association between GDF-15 protein levels and GDM was also observed in the middle pregnancy, with SMD (95% CI) of 0.53 (0.04-1.02). CONCLUSION: In all, our results suggested that the expression levels of GDF-15 were significantly higher in GDM patients compared with non-GDM pregnant women, especially in the late pregnancy. Frontiers Media S.A. 2023-01-20 /pmc/articles/PMC9895392/ /pubmed/36742413 http://dx.doi.org/10.3389/fendo.2023.1084896 Text en Copyright © 2023 Lu, Liu, Zhang, Liang, Zhu, Xiao, Wang, Ding, Banerjee, Yin and Ma https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Lu, Yi-Cheng Liu, Song-Liang Zhang, Yu-Shan Liang, Fei Zhu, Xiao-Yan Xiao, Yue Wang, Jing Ding, Cong Banerjee, Sudipta Yin, Jie-Yun Ma, Qiu-Ping Association between growth differentiation factor 15 levels and gestational diabetes mellitus: A combined analysis |
title | Association between growth differentiation factor 15 levels and gestational diabetes mellitus: A combined analysis |
title_full | Association between growth differentiation factor 15 levels and gestational diabetes mellitus: A combined analysis |
title_fullStr | Association between growth differentiation factor 15 levels and gestational diabetes mellitus: A combined analysis |
title_full_unstemmed | Association between growth differentiation factor 15 levels and gestational diabetes mellitus: A combined analysis |
title_short | Association between growth differentiation factor 15 levels and gestational diabetes mellitus: A combined analysis |
title_sort | association between growth differentiation factor 15 levels and gestational diabetes mellitus: a combined analysis |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895392/ https://www.ncbi.nlm.nih.gov/pubmed/36742413 http://dx.doi.org/10.3389/fendo.2023.1084896 |
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