Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy

Tumor-specific T cells are frequently exhausted by chronic antigenic stimulation. We here report on a human antigen-specific ex vivo model to explore new therapeutic options for T cell immunotherapies. T cells generated with this model resemble tumor-infiltrating exhausted T cells on a phenotypic an...

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Detalles Bibliográficos
Autores principales: Trefny, Marcel P., Kirchhammer, Nicole, Auf der Maur, Priska, Natoli, Marina, Schmid, Dominic, Germann, Markus, Fernandez Rodriguez, Laura, Herzig, Petra, Lötscher, Jonas, Akrami, Maryam, Stinchcombe, Jane C., Stanczak, Michal A., Zingg, Andreas, Buchi, Melanie, Roux, Julien, Marone, Romina, Don, Leyla, Lardinois, Didier, Wiese, Mark, Jeker, Lukas T., Bentires-Alj, Mohamed, Rossy, Jérémie, Thommen, Daniela S., Griffiths, Gillian M., Läubli, Heinz, Hess, Christoph, Zippelius, Alfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895440/
https://www.ncbi.nlm.nih.gov/pubmed/36732507
http://dx.doi.org/10.1038/s41467-022-35583-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895440/
https://www.ncbi.nlm.nih.gov/pubmed/36732507
http://dx.doi.org/10.1038/s41467-022-35583-w

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