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Dupilumab for the treatment of prurigo nodularis: A systematic review

BACKGROUND: Conventional treatment techniques have limited efficacy and more side effects in the treatment of prurigo nodularis. The better alternative treatment option for better outcomes of the disease is dupilumab. OBJECTIVE: The objective of this study was to systematically review dupilumab-rela...

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Autores principales: Cao, Peng, Xu, Wenjing, Jiang, Shuyi, Zhang, Litao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895771/
https://www.ncbi.nlm.nih.gov/pubmed/36742321
http://dx.doi.org/10.3389/fimmu.2023.1092685
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author Cao, Peng
Xu, Wenjing
Jiang, Shuyi
Zhang, Litao
author_facet Cao, Peng
Xu, Wenjing
Jiang, Shuyi
Zhang, Litao
author_sort Cao, Peng
collection PubMed
description BACKGROUND: Conventional treatment techniques have limited efficacy and more side effects in the treatment of prurigo nodularis. The better alternative treatment option for better outcomes of the disease is dupilumab. OBJECTIVE: The objective of this study was to systematically review dupilumab-related treatment outcomes in prurigo nodularis. METHODS: Several databases like Embase, PubMed, Web of Science, and Cochrane library were searched for data acquisition on October 8, 2022. Based on Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, 24 publications were included in this study. RESULTS: After 4,12,16 and more than 16 weeks of dupilumab treatment, 8.3% (n=5/60), 34.4% (n=11/32), 3.6% (n=2/56), and 45.3% (n=29/64) of patients had complete remission, respectively. In addition, 85.0% (n=51/60), 59.4% (n=19/32), 83.9% (n=47/56), and 43.8% (n=28/64) had partial remission, respectively. Moreover, 6.7% (n=4/60), 6.3% (n=2/32), 12.5% (n=7/56), and 10.9% (n=7/64) showed no remission, respectively, and significant reduction of numeric rating scale itch intensity (from 9.0 to 4.9, 2.1, 2.8, 0.9) was attained. There were no serious adverse events observed during treatment, but the most common event observed was conjunctivitis (12.6%, n=15/119). CONCLUSIONS: Dupilumab has definite effectiveness and safety in prurigo nodularis treatment. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO, identifier (CRD42022365802).
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spelling pubmed-98957712023-02-04 Dupilumab for the treatment of prurigo nodularis: A systematic review Cao, Peng Xu, Wenjing Jiang, Shuyi Zhang, Litao Front Immunol Immunology BACKGROUND: Conventional treatment techniques have limited efficacy and more side effects in the treatment of prurigo nodularis. The better alternative treatment option for better outcomes of the disease is dupilumab. OBJECTIVE: The objective of this study was to systematically review dupilumab-related treatment outcomes in prurigo nodularis. METHODS: Several databases like Embase, PubMed, Web of Science, and Cochrane library were searched for data acquisition on October 8, 2022. Based on Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, 24 publications were included in this study. RESULTS: After 4,12,16 and more than 16 weeks of dupilumab treatment, 8.3% (n=5/60), 34.4% (n=11/32), 3.6% (n=2/56), and 45.3% (n=29/64) of patients had complete remission, respectively. In addition, 85.0% (n=51/60), 59.4% (n=19/32), 83.9% (n=47/56), and 43.8% (n=28/64) had partial remission, respectively. Moreover, 6.7% (n=4/60), 6.3% (n=2/32), 12.5% (n=7/56), and 10.9% (n=7/64) showed no remission, respectively, and significant reduction of numeric rating scale itch intensity (from 9.0 to 4.9, 2.1, 2.8, 0.9) was attained. There were no serious adverse events observed during treatment, but the most common event observed was conjunctivitis (12.6%, n=15/119). CONCLUSIONS: Dupilumab has definite effectiveness and safety in prurigo nodularis treatment. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO, identifier (CRD42022365802). Frontiers Media S.A. 2023-01-20 /pmc/articles/PMC9895771/ /pubmed/36742321 http://dx.doi.org/10.3389/fimmu.2023.1092685 Text en Copyright © 2023 Cao, Xu, Jiang and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Cao, Peng
Xu, Wenjing
Jiang, Shuyi
Zhang, Litao
Dupilumab for the treatment of prurigo nodularis: A systematic review
title Dupilumab for the treatment of prurigo nodularis: A systematic review
title_full Dupilumab for the treatment of prurigo nodularis: A systematic review
title_fullStr Dupilumab for the treatment of prurigo nodularis: A systematic review
title_full_unstemmed Dupilumab for the treatment of prurigo nodularis: A systematic review
title_short Dupilumab for the treatment of prurigo nodularis: A systematic review
title_sort dupilumab for the treatment of prurigo nodularis: a systematic review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895771/
https://www.ncbi.nlm.nih.gov/pubmed/36742321
http://dx.doi.org/10.3389/fimmu.2023.1092685
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