Unraveling multilayered extracellular vesicles: Speculation on cause

Extracellular vesicles (EVs) are cell‐released, heterogenous nanoparticles that play important roles in (patho)physiological processes through intercellular communication. EVs are often depicted as having a single lipid bilayer, but many studies have demonstrated the existence of multilayered EVs. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Broad, Kelly, Walker, Sierra A., Davidovich, Irina, Witwer, Kenneth, Talmon, Yeshayahu, Wolfram, Joy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895808/
https://www.ncbi.nlm.nih.gov/pubmed/36732941
http://dx.doi.org/10.1002/jev2.12309
_version_ 1784881923832676352
author Broad, Kelly
Walker, Sierra A.
Davidovich, Irina
Witwer, Kenneth
Talmon, Yeshayahu
Wolfram, Joy
author_facet Broad, Kelly
Walker, Sierra A.
Davidovich, Irina
Witwer, Kenneth
Talmon, Yeshayahu
Wolfram, Joy
author_sort Broad, Kelly
collection PubMed
description Extracellular vesicles (EVs) are cell‐released, heterogenous nanoparticles that play important roles in (patho)physiological processes through intercellular communication. EVs are often depicted as having a single lipid bilayer, but many studies have demonstrated the existence of multilayered EVs. There has been minimal inquiry into differences between unilamellar and multilamellar EVs in terms of biogenesis mechanisms and functional effects. This commentary speculates on potential causes and roles of multilamellar EVs and serves as a call to action for the research community to unravel the complex layers of EVs.
format Online
Article
Text
id pubmed-9895808
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-98958082023-02-08 Unraveling multilayered extracellular vesicles: Speculation on cause Broad, Kelly Walker, Sierra A. Davidovich, Irina Witwer, Kenneth Talmon, Yeshayahu Wolfram, Joy J Extracell Vesicles Letter to the Editor Extracellular vesicles (EVs) are cell‐released, heterogenous nanoparticles that play important roles in (patho)physiological processes through intercellular communication. EVs are often depicted as having a single lipid bilayer, but many studies have demonstrated the existence of multilayered EVs. There has been minimal inquiry into differences between unilamellar and multilamellar EVs in terms of biogenesis mechanisms and functional effects. This commentary speculates on potential causes and roles of multilamellar EVs and serves as a call to action for the research community to unravel the complex layers of EVs. John Wiley and Sons Inc. 2023-02-02 2023-02 /pmc/articles/PMC9895808/ /pubmed/36732941 http://dx.doi.org/10.1002/jev2.12309 Text en © 2023 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to the Editor
Broad, Kelly
Walker, Sierra A.
Davidovich, Irina
Witwer, Kenneth
Talmon, Yeshayahu
Wolfram, Joy
Unraveling multilayered extracellular vesicles: Speculation on cause
title Unraveling multilayered extracellular vesicles: Speculation on cause
title_full Unraveling multilayered extracellular vesicles: Speculation on cause
title_fullStr Unraveling multilayered extracellular vesicles: Speculation on cause
title_full_unstemmed Unraveling multilayered extracellular vesicles: Speculation on cause
title_short Unraveling multilayered extracellular vesicles: Speculation on cause
title_sort unraveling multilayered extracellular vesicles: speculation on cause
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895808/
https://www.ncbi.nlm.nih.gov/pubmed/36732941
http://dx.doi.org/10.1002/jev2.12309
work_keys_str_mv AT broadkelly unravelingmultilayeredextracellularvesiclesspeculationoncause
AT walkersierraa unravelingmultilayeredextracellularvesiclesspeculationoncause
AT davidovichirina unravelingmultilayeredextracellularvesiclesspeculationoncause
AT witwerkenneth unravelingmultilayeredextracellularvesiclesspeculationoncause
AT talmonyeshayahu unravelingmultilayeredextracellularvesiclesspeculationoncause
AT wolframjoy unravelingmultilayeredextracellularvesiclesspeculationoncause

Ejemplares similares