Cargando…
Addressing persistent evidence gaps in cardiovascular sex differences research – the potential of clinical care data
Women have historically been underrepresented in cardiovascular clinical trials, resulting in a lack of sex-specific data. This is especially problematic in two situations, namely those where diseases manifest differently in women and men and those where biological differences between the sexes migh...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895823/ https://www.ncbi.nlm.nih.gov/pubmed/36741297 http://dx.doi.org/10.3389/fgwh.2022.1006425 |
_version_ | 1784881927541489664 |
---|---|
author | Bots, Sophie H. Onland-Moret, N. Charlotte den Ruijter, Hester M. |
author_facet | Bots, Sophie H. Onland-Moret, N. Charlotte den Ruijter, Hester M. |
author_sort | Bots, Sophie H. |
collection | PubMed |
description | Women have historically been underrepresented in cardiovascular clinical trials, resulting in a lack of sex-specific data. This is especially problematic in two situations, namely those where diseases manifest differently in women and men and those where biological differences between the sexes might affect the efficacy and/or safety of medication. There is therefore a pressing need for datasets with proper representation of women to address questions related to these situations. Clinical care data could fit this bill nicely because of their unique broad scope across both patient groups and clinical measures. This perspective piece presents the potential of clinical care data in sex differences research and discusses current challenges clinical care data-based research faces. It also suggests strategies to reduce the effect of these limitations, and explores whether clinical care data alone will be sufficient to close evidence gaps or whether a more comprehensive approach is needed. |
format | Online Article Text |
id | pubmed-9895823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98958232023-02-04 Addressing persistent evidence gaps in cardiovascular sex differences research – the potential of clinical care data Bots, Sophie H. Onland-Moret, N. Charlotte den Ruijter, Hester M. Front Glob Womens Health Global Women's Health Women have historically been underrepresented in cardiovascular clinical trials, resulting in a lack of sex-specific data. This is especially problematic in two situations, namely those where diseases manifest differently in women and men and those where biological differences between the sexes might affect the efficacy and/or safety of medication. There is therefore a pressing need for datasets with proper representation of women to address questions related to these situations. Clinical care data could fit this bill nicely because of their unique broad scope across both patient groups and clinical measures. This perspective piece presents the potential of clinical care data in sex differences research and discusses current challenges clinical care data-based research faces. It also suggests strategies to reduce the effect of these limitations, and explores whether clinical care data alone will be sufficient to close evidence gaps or whether a more comprehensive approach is needed. Frontiers Media S.A. 2023-01-20 /pmc/articles/PMC9895823/ /pubmed/36741297 http://dx.doi.org/10.3389/fgwh.2022.1006425 Text en © 2023 Bots, Onland-Moret and den Ruijter. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Global Women's Health Bots, Sophie H. Onland-Moret, N. Charlotte den Ruijter, Hester M. Addressing persistent evidence gaps in cardiovascular sex differences research – the potential of clinical care data |
title | Addressing persistent evidence gaps in cardiovascular sex differences research – the potential of clinical care data |
title_full | Addressing persistent evidence gaps in cardiovascular sex differences research – the potential of clinical care data |
title_fullStr | Addressing persistent evidence gaps in cardiovascular sex differences research – the potential of clinical care data |
title_full_unstemmed | Addressing persistent evidence gaps in cardiovascular sex differences research – the potential of clinical care data |
title_short | Addressing persistent evidence gaps in cardiovascular sex differences research – the potential of clinical care data |
title_sort | addressing persistent evidence gaps in cardiovascular sex differences research – the potential of clinical care data |
topic | Global Women's Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895823/ https://www.ncbi.nlm.nih.gov/pubmed/36741297 http://dx.doi.org/10.3389/fgwh.2022.1006425 |
work_keys_str_mv | AT botssophieh addressingpersistentevidencegapsincardiovascularsexdifferencesresearchthepotentialofclinicalcaredata AT onlandmoretncharlotte addressingpersistentevidencegapsincardiovascularsexdifferencesresearchthepotentialofclinicalcaredata AT denruijterhesterm addressingpersistentevidencegapsincardiovascularsexdifferencesresearchthepotentialofclinicalcaredata |