Cargando…

Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) represents the most lethal subtype of breast cancer due to its aggressive clinical features and the lack of effective therapeutic targets. To identify novel approaches for targeting TNBC, we examined the role of protein phosphatases in TNBC progression and chemor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liao, Li, Zhang, Yin-Ling, Deng, Ling, Chen, Chao, Ma, Xiao-Yan, Andriani, Lisa, Yang, Shao-Ying, Hu, Shu-Yuan, Zhang, Fang-Lin, Shao, Zhi-Min, Li, Da-Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Translational Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896024/ https://www.ncbi.nlm.nih.gov/pubmed/36484700 http://dx.doi.org/10.1158/0008-5472.CAN-22-2709

Ejemplares similares

Activation of an AKT/FOXM1/STMN1 pathway drives resistance to tyrosine kinase inhibitors in lung cancer
por: Li, Meng, et al.
Publicado: (2017)

High STMN1 level is associated with chemo-resistance and poor prognosis in gastric cancer patients
por: Bai, Tuya, et al.
Publicado: (2017)

Differential pattern of glycogen accumulation after protein phosphatase 1 glycogen-targeting subunit PPP1R6 overexpression, compared to PPP1R3C and PPP1R3A, in skeletal muscle cells
por: Montori-Grau, Marta, et al.
Publicado: (2011)

The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts
por: Lang, Irene, et al.
Publicado: (2020)

Protein phosphatase 1 regulatory subunit 3G (PPP1R3G) correlates with poor prognosis and immune infiltration in lung adenocarcinoma
por: Zhuo, Xingli, et al.
Publicado: (2021)

MiR-770 suppresses the chemo-resistance and metastasis of triple negative breast cancer via direct targeting of STMN1
por: Li, Yaming, et al.
Publicado: (2018)

Impact of Social Defeat Stress on DNA Methylation in Drd2, Nr3c1, and Stmn1 in Wild-type and Stmn1 Knock-out Mice
por: Oh, Young-Eun, et al.
Publicado: (2022)

Interaction of Structural Glycoprotein E2 of Classical Swine Fever Virus with Protein Phosphatase 1 Catalytic Subunit Beta (PPP1CB)
por: Vuono, Elizabeth A., et al.
Publicado: (2019)

BRCA1 and STMN1 as prognostic markers in NSCLCs who received cisplatin-based adjuvant chemotherapy
por: Wang, Mingxing, et al.
Publicado: (2017)

Stress hormones reduce the efficacy of paclitaxel in triple negative breast cancer through induction of DNA damage
por: Reeder, A, et al.
Publicado: (2015)

STMN1 as a novel prognostic biomarker in HCC correlating with immune infiltrates and methylation
por: Zhang, En-di, et al.
Publicado: (2022)

CENPA-driven STMN1 Transcription Inhibits Ferroptosis in Hepatocellular Carcinoma
por: Liang, Daomiao, et al.
Publicado: (2023)

Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B
por: Krzyzosiak, Agnieszka, et al.
Publicado: (2018)

Structure-Function Analysis of PPP1R3D, a Protein Phosphatase 1 Targeting Subunit, Reveals a Binding Motif for 14-3-3 Proteins which Regulates its Glycogenic Properties
por: Rubio-Villena, Carla, et al.
Publicado: (2015)

PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1)
por: Luo, Peihua, et al.
Publicado: (2020)

STMN1 and MKI67 Are Upregulated in Uterine Leiomyosarcoma and Are Potential Biomarkers for its Diagnosis
por: Hu, Xianqing, et al.
Publicado: (2020)

Knockdown of STMN1 enhances osteosarcoma cell chemosensitivity through inhibition of autophagy
por: Wang, Zili, et al.
Publicado: (2017)

STMN1 accumulation is associated with dysplastic and neoplastic lesions in patients with ulcerative colitis
por: Osone, Katsuya, et al.
Publicado: (2019)

LncRNA PPP1R14B-AS1 Promotes Tumor Cell Proliferation and Migration via the Enhancement of Mitochondrial Respiration
por: Yang, Yibin, et al.
Publicado: (2020)

Clinical significance of UGT1A1 polymorphism and expression of ERCC1, BRCA1, TYMS, RRM1, TUBB3, STMN1 and TOP2A in gastric cancer
por: Cao, Yongkuan, et al.
Publicado: (2017)

PPP1R14B Is a Prognostic and Immunological Biomarker in Pan-Cancer
por: Deng, Mingxia, et al.
Publicado: (2021)

The involvement of FOXO1 in cytotoxic stress and drug-resistance induced by paclitaxel in ovarian cancers
por: Goto, T, et al.
Publicado: (2008)

Widespread presence of "bacterial-like" PPP phosphatases in eukaryotes
por: Andreeva, Alexandra V, et al.
Publicado: (2004)

The origin and radiation of the phosphoprotein phosphatase (PPP) enzymes of Eukaryotes
por: Kerk, David, et al.
Publicado: (2021)

Knockdown of actin-like 8 inhibits cell proliferation by regulating FOXM1, STMN1, PLK1, and BIRC5 in lung adenocarcinoma A549 cells
por: Ma, Shanwu, et al.
Publicado: (2019)

PPP1R12A is a recycling endosomal phosphatase that facilitates YAP activation
por: Inoue, Chiaki, et al.
Publicado: (2023)

miR-223 increases gallbladder cancer cell sensitivity to docetaxel by downregulating STMN1
por: Lu, Wei, et al.
Publicado: (2016)

ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells
por: Vaidyanathan, Aparajitha, et al.
Publicado: (2016)

LINC00466 Impacts Cell Proliferation, Metastasis and Sensitivity to Temozolomide of Glioma by Sponging miR-137 to Regulate PPP1R14B Expression
por: Zhao, Mingfei, et al.
Publicado: (2021)

Aberrantly high activation of a FoxM1–STMN1 axis contributes to progression and tumorigenesis in FoxM1-driven cancers
por: Liu, Jun, et al.
Publicado: (2021)

PP5 (PPP5C) is a phosphatase of Dvl2
por: Xie, Jianlei, et al.
Publicado: (2018)

ETHE1 Accelerates Triple-Negative Breast Cancer Metastasis by Activating GCN2/eIF2α/ATF4 Signaling
por: Yang, Shao-Ying, et al.
Publicado: (2023)

STMN1 Promotes Progesterone Production Via StAR Up-regulation in Mouse Granulosa Cells
por: Dou, Yun-De, et al.
Publicado: (2016)

Dual inhibition of BTLA and PD-1 can enhance therapeutic efficacy of paclitaxel on intraperitoneally disseminated tumors
por: Sun, Wei-Zen, et al.
Publicado: (2023)

Phase II multi-institutional prospective randomised trial comparing S-1+paclitaxel with S-1+cisplatin in patients with unresectable and/or recurrent advanced gastric cancer
por: Mochiki, E, et al.
Publicado: (2012)

Phosphoglycerate kinase-1 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in breast cancer
por: Sun, S, et al.
Publicado: (2015)

Identification of PP1c-PPP1R12A Substrates Using Kinase-Catalyzed Biotinylation to Identify Phosphatase Substrates
por: Dedigama-Arachchige, Pavithra M., et al.
Publicado: (2023)

Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer
por: Xie, Wenjun, et al.
Publicado: (2021)

High Tumoral STMN1 Expression Is Associated with Malignant Potential and Poor Prognosis in Patients with Neuroblastoma
por: Ogushi, Kenjiro, et al.
Publicado: (2023)

Waved with open eyelids 2 (woe2) is a novel spontaneous mouse mutation in the protein phosphatase 1, regulatory (inhibitor) subunit 13 like (Ppp1r13l) gene
por: Toonen, Joseph, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_14n27s2qkln79mq0kgmbb465j4