Single‐Cell and Spatial Transcriptomics Decodes Wharton's Jelly‐Derived Mesenchymal Stem Cells Heterogeneity and a Subpopulation with Wound Repair Signatures (Adv. Sci. 4/2023)

Wharton's Jelly‐Derived Mesenchymal Stem Cells In article number 2204786, Jinghua Chen, Liangwan Chen, Xiaosong Chen, and co‐workers chart a comprehensive spatiotemporal heterogeneity atlas of Wharton's jelly‐derived mesenchymal stem cells (WJ‐MSCs), finding that S100A9(+)CD29(+)CD142(+) W...

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Detalles Bibliográficos
Autores principales: Chen, Penghong, Tang, Shijie, Li, Ming, Wang, Dezhi, Chen, Caixiang, Qiu, Yiqun, Fang, Zhuoqun, Zhang, Haoruo, Gao, Hangqi, Weng, Haiyan, Hu, Kailun, Lin, Jian, Lin, Qingxia, Tan, Yi, Li, Shirong, Chen, Jinghua, Chen, Liangwan, Chen, Xiaosong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896030/
http://dx.doi.org/10.1002/advs.202370021
Descripción
Sumario:Wharton's Jelly‐Derived Mesenchymal Stem Cells In article number 2204786, Jinghua Chen, Liangwan Chen, Xiaosong Chen, and co‐workers chart a comprehensive spatiotemporal heterogeneity atlas of Wharton's jelly‐derived mesenchymal stem cells (WJ‐MSCs), finding that S100A9(+)CD29(+)CD142(+) WJ‐MSCs exhibit promising wound‐repair properties which is uncannily parallel to the cover story, Chinese myth of Nüwa mending the heaven. Nüwa (single‐cell omics) rushed out of riprap (mixed WJ‐MSCs) with the crystal stone (S100A9(+)CD29(+)CD142(+) WJ‐MSCs), and repaired the holes (skin wound) precisely. This study envisions important insights on cell subpopulations to novel therapeutic strategies for specific diseases. [Image: see text]

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