Single‐Cell and Spatial Transcriptomics Decodes Wharton's Jelly‐Derived Mesenchymal Stem Cells Heterogeneity and a Subpopulation with Wound Repair Signatures (Adv. Sci. 4/2023)

Wharton's Jelly‐Derived Mesenchymal Stem Cells In article number 2204786, Jinghua Chen, Liangwan Chen, Xiaosong Chen, and co‐workers chart a comprehensive spatiotemporal heterogeneity atlas of Wharton's jelly‐derived mesenchymal stem cells (WJ‐MSCs), finding that S100A9(+)CD29(+)CD142(+) W...

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Autores principales: Chen, Penghong, Tang, Shijie, Li, Ming, Wang, Dezhi, Chen, Caixiang, Qiu, Yiqun, Fang, Zhuoqun, Zhang, Haoruo, Gao, Hangqi, Weng, Haiyan, Hu, Kailun, Lin, Jian, Lin, Qingxia, Tan, Yi, Li, Shirong, Chen, Jinghua, Chen, Liangwan, Chen, Xiaosong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896030/
http://dx.doi.org/10.1002/advs.202370021
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author Chen, Penghong
Tang, Shijie
Li, Ming
Wang, Dezhi
Chen, Caixiang
Qiu, Yiqun
Fang, Zhuoqun
Zhang, Haoruo
Gao, Hangqi
Weng, Haiyan
Hu, Kailun
Lin, Jian
Lin, Qingxia
Tan, Yi
Li, Shirong
Chen, Jinghua
Chen, Liangwan
Chen, Xiaosong
author_facet Chen, Penghong
Tang, Shijie
Li, Ming
Wang, Dezhi
Chen, Caixiang
Qiu, Yiqun
Fang, Zhuoqun
Zhang, Haoruo
Gao, Hangqi
Weng, Haiyan
Hu, Kailun
Lin, Jian
Lin, Qingxia
Tan, Yi
Li, Shirong
Chen, Jinghua
Chen, Liangwan
Chen, Xiaosong
author_sort Chen, Penghong
collection PubMed
description Wharton's Jelly‐Derived Mesenchymal Stem Cells In article number 2204786, Jinghua Chen, Liangwan Chen, Xiaosong Chen, and co‐workers chart a comprehensive spatiotemporal heterogeneity atlas of Wharton's jelly‐derived mesenchymal stem cells (WJ‐MSCs), finding that S100A9(+)CD29(+)CD142(+) WJ‐MSCs exhibit promising wound‐repair properties which is uncannily parallel to the cover story, Chinese myth of Nüwa mending the heaven. Nüwa (single‐cell omics) rushed out of riprap (mixed WJ‐MSCs) with the crystal stone (S100A9(+)CD29(+)CD142(+) WJ‐MSCs), and repaired the holes (skin wound) precisely. This study envisions important insights on cell subpopulations to novel therapeutic strategies for specific diseases. [Image: see text]
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spelling pubmed-98960302023-02-08 Single‐Cell and Spatial Transcriptomics Decodes Wharton's Jelly‐Derived Mesenchymal Stem Cells Heterogeneity and a Subpopulation with Wound Repair Signatures (Adv. Sci. 4/2023) Chen, Penghong Tang, Shijie Li, Ming Wang, Dezhi Chen, Caixiang Qiu, Yiqun Fang, Zhuoqun Zhang, Haoruo Gao, Hangqi Weng, Haiyan Hu, Kailun Lin, Jian Lin, Qingxia Tan, Yi Li, Shirong Chen, Jinghua Chen, Liangwan Chen, Xiaosong Adv Sci (Weinh) Frontispiece Wharton's Jelly‐Derived Mesenchymal Stem Cells In article number 2204786, Jinghua Chen, Liangwan Chen, Xiaosong Chen, and co‐workers chart a comprehensive spatiotemporal heterogeneity atlas of Wharton's jelly‐derived mesenchymal stem cells (WJ‐MSCs), finding that S100A9(+)CD29(+)CD142(+) WJ‐MSCs exhibit promising wound‐repair properties which is uncannily parallel to the cover story, Chinese myth of Nüwa mending the heaven. Nüwa (single‐cell omics) rushed out of riprap (mixed WJ‐MSCs) with the crystal stone (S100A9(+)CD29(+)CD142(+) WJ‐MSCs), and repaired the holes (skin wound) precisely. This study envisions important insights on cell subpopulations to novel therapeutic strategies for specific diseases. [Image: see text] John Wiley and Sons Inc. 2023-02-03 /pmc/articles/PMC9896030/ http://dx.doi.org/10.1002/advs.202370021 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Frontispiece
Chen, Penghong
Tang, Shijie
Li, Ming
Wang, Dezhi
Chen, Caixiang
Qiu, Yiqun
Fang, Zhuoqun
Zhang, Haoruo
Gao, Hangqi
Weng, Haiyan
Hu, Kailun
Lin, Jian
Lin, Qingxia
Tan, Yi
Li, Shirong
Chen, Jinghua
Chen, Liangwan
Chen, Xiaosong
Single‐Cell and Spatial Transcriptomics Decodes Wharton's Jelly‐Derived Mesenchymal Stem Cells Heterogeneity and a Subpopulation with Wound Repair Signatures (Adv. Sci. 4/2023)
title Single‐Cell and Spatial Transcriptomics Decodes Wharton's Jelly‐Derived Mesenchymal Stem Cells Heterogeneity and a Subpopulation with Wound Repair Signatures (Adv. Sci. 4/2023)
title_full Single‐Cell and Spatial Transcriptomics Decodes Wharton's Jelly‐Derived Mesenchymal Stem Cells Heterogeneity and a Subpopulation with Wound Repair Signatures (Adv. Sci. 4/2023)
title_fullStr Single‐Cell and Spatial Transcriptomics Decodes Wharton's Jelly‐Derived Mesenchymal Stem Cells Heterogeneity and a Subpopulation with Wound Repair Signatures (Adv. Sci. 4/2023)
title_full_unstemmed Single‐Cell and Spatial Transcriptomics Decodes Wharton's Jelly‐Derived Mesenchymal Stem Cells Heterogeneity and a Subpopulation with Wound Repair Signatures (Adv. Sci. 4/2023)
title_short Single‐Cell and Spatial Transcriptomics Decodes Wharton's Jelly‐Derived Mesenchymal Stem Cells Heterogeneity and a Subpopulation with Wound Repair Signatures (Adv. Sci. 4/2023)
title_sort single‐cell and spatial transcriptomics decodes wharton's jelly‐derived mesenchymal stem cells heterogeneity and a subpopulation with wound repair signatures (adv. sci. 4/2023)
topic Frontispiece
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896030/
http://dx.doi.org/10.1002/advs.202370021
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