Cargando…

Loss‐of‐Function of p21‐Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects

Closure of the neural tube represents a highly complex and coordinated process, the failure of which constitutes common birth defects. The serine/threonine kinase p21‐activated kinase 2 (PAK2) is a critical regulator of cytoskeleton dynamics; however, its role in the neurulation and pathogenesis of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yan, Zhang, Kaifan, Guo, Jin, Yang, Shuyan, Shi, Xiaohui, Pan, Jinrong, Sun, Zheng, Zou, Jizhen, Li, Yi, Li, Yuanyuan, Fan, Tianda, Song, Wei, Cheng, Fang, Zeng, Cheng, Li, Jinchen, Zhang, Ting, Sun, Zhong Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896034/ https://www.ncbi.nlm.nih.gov/pubmed/36504449 http://dx.doi.org/10.1002/advs.202204018

Ejemplares similares

The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders
por: Zhang, Kaifan, et al.
Publicado: (2020)

Association between rare variants in specific functional pathways and human neural tube defects multiple subphenotypes
por: Zou, Jizhen, et al.
Publicado: (2020)

F-box protein FBXO30 mediates retinoic acid receptor γ ubiquitination and regulates BMP signaling in neural tube defects
por: Cheng, Xiyue, et al.
Publicado: (2019)

BMP/Smad Pathway Is Involved in Lithium Carbonate-Induced Neural-Tube Defects in Mice and Neural Stem Cells
por: Yang, Aiyun, et al.
Publicado: (2022)

Tcf4 Controls Neuronal Migration of the Cerebral Cortex through Regulation of Bmp7
por: Chen, Tianda, et al.
Publicado: (2016)

Maternal prenatal screening programs that predict trisomy 21, trisomy 18, and neural tube defects in offspring
por: Chen, Yiming, et al.
Publicado: (2023)

Neural tube defects in 21st century: is Northern Ireland changing?
por: Dabir, Tabib, et al.
Publicado: (2009)

Detection of Copy Number Variants Reveals Association of Cilia Genes with Neural Tube Defects
por: Chen, Xiaoli, et al.
Publicado: (2013)

Restoring BMP4 expression in vascular endothelial progenitors ameliorates maternal diabetes-induced apoptosis and neural tube defects
por: Cao, Songying, et al.
Publicado: (2020)

Integrative analysis prioritised oxytocin-related biomarkers associated with the aetiology of autism spectrum disorder
por: Wang, Tao, et al.
Publicado: (2022)

Dentinogenesis and Tooth-Alveolar Bone Complex Defects in BMP9/GDF2 Knockout Mice
por: Huang, Xia, et al.
Publicado: (2019)

Genetic Variants in the Folate Pathway and the Risk of Neural Tube Defects: A Meta-Analysis of the Published Literature
por: Zhang, Ti, et al.
Publicado: (2013)

Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy
por: Wang, Fang, et al.
Publicado: (2017)

Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice
por: Wang, Bin, et al.
Publicado: (2018)

Bone induction and defect repair by true bone ceramics incorporated with rhBMP-2 and Sr
por: Zhang, Chunli, et al.
Publicado: (2021)

BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis
por: Xu, Jing-zun, et al.
Publicado: (2022)

Ethionine-mediated reduction of S-adenosylmethionine is responsible for the neural tube defects in the developing mouse embryo-mediated m6A modification and is involved in neural tube defects via modulating Wnt/β-catenin signaling pathway
por: Zhang, Li, et al.
Publicado: (2021)

The BMP ligand Pinhead together with Admp supports the robustness of embryonic patterning
por: Yan, Yifang, et al.
Publicado: (2019)

Correction to: BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis
por: Xu, Jing-zun, et al.
Publicado: (2022)

Drosophila S6 Kinase Like Inhibits Neuromuscular Junction Growth by Downregulating the BMP Receptor Thickveins
por: Zhao, Guoli, et al.
Publicado: (2015)

Abnormal methylation caused by folic acid deficiency in neural tube defects
por: Cao, Rui, et al.
Publicado: (2022)

miR-21 synergizes with BMP9 in osteogenic differentiation by activating the BMP9/Smad signaling pathway in murine multilineage cells
por: SONG, QILING, et al.
Publicado: (2015)

Analysis of Genes Associated with Both Neural Tube Defects and Neuroectodermal Tumors
por: Cao, Rui, et al.
Publicado: (2022)

Expression Of BMP7 In Ovarian Cancer And Biological Effect Of BMP7 Knockdown On Ovarian Cancer Cells
por: Guan, Hongwei, et al.
Publicado: (2019)

Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling
por: Li, Wenqing, et al.
Publicado: (2017)

Heterotopic ossification related to the use of recombinant human BMP-2 in osteonecrosis of femoral head
por: Shi, Lijun, et al.
Publicado: (2017)

New cut-off values for screening of trisomy 21, 18 and open neural tube defects (ONTD) during the second trimester in pregnant women with advanced maternal age
por: Chen, Yiming, et al.
Publicado: (2020)

Injectable BMP‐2 gene‐activated scaffold for the repair of cranial bone defect in mice
por: Sun, Kai, et al.
Publicado: (2020)

Nicotinamide adenine dinucleotide kinase promotes lymph node metastasis of NSCLC via activating ID1 expression through BMP pathway
por: Zeng, Zimei, et al.
Publicado: (2023)

Clomiphene and neural tube defects.
por: Nevin, N. C., et al.
Publicado: (1976)

Epidemiology of neural tube defects
por: Al-Mendalawi, Mahmood D.
Publicado: (2015)

Epidemiology of neural tube defects
por: Seidahmed, Mohammed Z., et al.
Publicado: (2014)

Junctional Neural Tube Defect
por: Eibach, Sebastian, et al.
Publicado: (2020)

Cefazolin/BMP-2-Loaded Mesoporous Silica Nanoparticles for the Repair of Open Fractures with Bone Defects
por: Shen, Mingkui, et al.
Publicado: (2022)

Matrigel scaffold combined with Ad-hBMP7-transfected chondrocytes improves the repair of rabbit cartilage defect
por: Xia, Xiaopeng, et al.
Publicado: (2017)

Genetic mutations in ribosomal biogenesis gene TCOF1 identified in human neural tube defects
por: Wang, Fang, et al.
Publicado: (2023)

BMP signaling is required for nkx2.3-positive pharyngeal pouch progenitor specification in zebrafish
por: Li, Linwei, et al.
Publicado: (2019)

Loss of BMP2 and BMP4 Signaling in the Dental Epithelium Causes Defective Enamel Maturation and Aberrant Development of Ameloblasts
por: Reibring, Claes-Göran, et al.
Publicado: (2022)

Inositol, neural tube closure and the prevention of neural tube defects
por: Greene, Nicholas D.E., et al.
Publicado: (2017)

Silencing BMP-2 expression inhibits A549 and H460 cell proliferation and migration
por: Chu, Heying, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_5fvbmt14hgsa007l727bk0pebi