A “grappling hook” interaction connects self-assembly and chaperone activity of Nucleophosmin 1

How the self-assembly of partially disordered proteins generates functional compartments in the cytoplasm and particularly in the nucleus is poorly understood. Nucleophosmin 1 (NPM1) is an abundant nucleolar protein that forms large oligomers and undergoes liquid–liquid phase separation by binding R...

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Detalles Bibliográficos
Autores principales: Saluri, Mihkel, Leppert, Axel, Gese, Genis Valentin, Sahin, Cagla, Lama, Dilraj, Kaldmäe, Margit, Chen, Gefei, Elofsson, Arne, Allison, Timothy M, Arsenian-Henriksson, Marie, Johansson, Jan, Lane, David P, Hällberg, B Martin, Landreh, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896144/
https://www.ncbi.nlm.nih.gov/pubmed/36743470
http://dx.doi.org/10.1093/pnasnexus/pgac303

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