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BRCA1 deficiency in mature CD8(+) T lymphocytes impairs antitumor immunity

Women with BRCA1 germline mutations have approximately an 80% lifetime chance of developing breast cancer. While the tumor suppressor function of BRCA1 in breast epithelium has been studied extensively, it is not clear whether BRCA1 deficiency in non-breast somatic cells also contribute to tumorigen...

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Detalles Bibliográficos
Autores principales:	Wu, Bogang, Qi, Leilei, Chiang, Huai-Chin, Pan, Haihui, Zhang, Xiaowen, Greenbaum, Alexandra, Stark, Elizabeth, Wang, Li-Ju, Chen, Yidong, Haddad, Bassem R., Clagett, Dionyssia, Isaacs, Claudine, Elledge, Richard, Horvath, Anelia, Hu, Yanfen, Li, Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896206/ https://www.ncbi.nlm.nih.gov/pubmed/36731891 http://dx.doi.org/10.1136/jitc-2022-005852

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