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TIPE2 deletion improves the therapeutic potential of adoptively transferred NK cells

BACKGROUND: To enhance the efficacy of adoptive NK cell therapy against solid tumors, NK cells must be modified to resist exhaustion in the tumor microenvironment (TME). However, the molecular checkpoint underlying NK cell exhaustion in the TME remains elusive. METHODS: We analyzed the correlation b...

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Detalles Bibliográficos
Autores principales:	Bi, Jiacheng, Huang, Chen, Jin, Xiaomeng, Zheng, Chaoyue, Huang, Yingying, Zheng, Xiaohu, Tian, Zhigang, Sun, Haoyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896240/ https://www.ncbi.nlm.nih.gov/pubmed/36725083 http://dx.doi.org/10.1136/jitc-2022-006002

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