Cargando…

Evaluation of neurotrophic factor secreting mesenchymal stem cells in progressive multiple sclerosis

BACKGROUND: Autologous mesenchymal stem cell neurotrophic factor–secreting cells (NurOwn(®)) have the potential to modify underlying disease mechanisms in progressive multiple sclerosis (PMS). OBJECTIVE: This open-label phase II study was conducted to evaluate safety/efficacy of three intrathecal ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cohen, Jeffrey A, Lublin, Fred D, Lock, Christoper, Pelletier, Daniel, Chitnis, Tanuja, Mehra, Munish, Gothelf, Yael, Aricha, Revital, Lindborg, Stacy, Lebovits, Chaim, Levy, Yossef, Motamed Khorasani, Afsaneh, Kern, Ralph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2022
Materias:	Original Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896300/ https://www.ncbi.nlm.nih.gov/pubmed/36113170 http://dx.doi.org/10.1177/13524585221122156

Ejemplares similares

MSC-NTF (NurOwn®) exosomes: a novel therapeutic modality in the mouse LPS-induced ARDS model
por: Kaspi, Haggai, et al.
Publicado: (2021)

miRNA profiling of NurOwn®: mesenchymal stem cells secreting neurotrophic factors
por: Gothelf, Yael, et al.
Publicado: (2017)

A randomized placebo‐controlled phase 3 study of mesenchymal stem cells induced to secrete high levels of neurotrophic factors in amyotrophic lateral sclerosis
por: Cudkowicz, Merit E., et al.
Publicado: (2022)

NurOwn, phase 2, randomized, clinical trial in patients with ALS: Safety, clinical, and biomarker results
por: Berry, James D., et al.
Publicado: (2019)

Safety of repeated transplantations of neurotrophic factors-secreting human mesenchymal stromal stem cells
por: Gothelf, Yael, et al.
Publicado: (2014)

Addressing heterogeneity in amyotrophic lateral sclerosis CLINICAL TRIALS
por: Goyal, Namita A., et al.
Publicado: (2020)

The Role of CD4 T Cells in the Pathogenesis of Multiple Sclerosis
por: Chitnis, Tanuja
Publicado: (2007)

MuSK EAMG: Immunological Characterization and Suppression by Induction of Oral Tolerance
por: Reuveni, Debby, et al.
Publicado: (2020)

Pathophysiology of myelin oligodendrocyte glycoprotein antibody disease
por: Corbali, Osman, et al.
Publicado: (2023)

Plasma neurofilament light chain in children with relapsing MS receiving teriflunomide or placebo: A post hoc analysis of the randomized TERIKIDS trial
por: Kuhle, Jens, et al.
Publicado: (2023)

Relapsing experimental allergic encephalomyelitis an autoimmune model of multiple sclerosis
por: Lublin, Fred D.
Publicado: (1985)

How patients with multiple sclerosis acquire disability
por: Lublin, Fred D, et al.
Publicado: (2022)

Ketamine use in refractory status epilepticus associated with anti-NMDA receptor antibody encephalitis()
por: Santoro, Jonathan D., et al.
Publicado: (2019)

Blood neurofilament light: a critical review of its application to neurologic disease
por: Barro, Christian, et al.
Publicado: (2020)

Interplay Between Endocrine Disruptors and Immunity: Implications for Diseases of Autoreactive Etiology
por: Popescu, Maria, et al.
Publicado: (2021)

Confirmed disability progression provides limited predictive information regarding future disease progression in multiple sclerosis
por: Healy, Brian C, et al.
Publicado: (2021)

Positive Predictive Value of MOG-IgG for Clinically Defined MOG-AD Within a Real-World Cohort
por: Manzano, Giovanna S., et al.
Publicado: (2022)

Preventing Multiple Sclerosis: The Pediatric Perspective
por: Hardy, Duriel, et al.
Publicado: (2022)

Symptom Interconnectivity in Multiple Sclerosis: A Narrative Review of Potential Underlying Biological Disease Processes
por: Chitnis, Tanuja, et al.
Publicado: (2022)

The emotional-behavioral state of Israeli adolescent and young adult females with anorexia nervosa during the COVID19 pandemic
por: Serur, Yaffa, et al.
Publicado: (2022)

Immunology of neuromyelitis optica during pregnancy
por: Davoudi, Vahid, et al.
Publicado: (2016)

Thalidomide and neurotrophism
por: Soper, Judith R., et al.
Publicado: (2018)

Regional Gray Matter Atrophy in Relapsing Remitting Multiple Sclerosis: Baseline Analysis of Multi-Center Data
por: Datta, Sushmita, et al.
Publicado: (2015)

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression
por: Levy, Marion J. F., et al.
Publicado: (2018)

Genetic and Epigenetic Regulation of the Brain-Derived Neurotrophic Factor in the Central Nervous System
por: Martínez-Levy, Gabriela A., et al.
Publicado: (2014)

Assessment of Definitions of Sustained Disease Progression in Relapsing-Remitting Multiple Sclerosis
por: Healy, Brian C., et al.
Publicado: (2013)

Validation of Two Kinetic Assays for the Quantification of Endotoxin in Human Serum
por: Barro, Christian, et al.
Publicado: (2021)

Aging and efficacy of disease-modifying therapies in multiple sclerosis: a meta-analysis of clinical trials
por: Zhang, Yinan, et al.
Publicado: (2020)

Identification of TNFAIP3 as relapse biomarker and potential therapeutic target for MOG antibody associated diseases
por: Saxena, Shrishti, et al.
Publicado: (2020)

Neurotrophic Factor Artemin Promotes Invasiveness and Neurotrophic Function of Pancreatic Adenocarcinoma In Vivo and In Vitro
por: Gao, Li, et al.
Publicado: (2015)

Diagnosis and management of neurotrophic keratitis
por: Sacchetti, Marta, et al.
Publicado: (2014)

Neurotrophic Factors in Health and Disease
por: Severini, Cinzia
Publicado: (2022)

Melatonin: A Neurotrophic Factor?
por: Miranda-Riestra, Armida, et al.
Publicado: (2022)

The neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are independently associated with neurological disability and brain atrophy in multiple sclerosis
por: Hemond, Christopher C., et al.
Publicado: (2019)

Experience with long-term rituximab use in a multiple sclerosis clinic
por: Barra, Megan E, et al.
Publicado: (2016)

Regional cortical thickness in relapsing remitting multiple sclerosis: A multi-center study()
por: Narayana, Ponnada A., et al.
Publicado: (2012)

Differential effects of brain-derived neurotrophic factor and neurotrophin-3 on hindlimb function in paraplegic rats
por: Boyce, Vanessa S, et al.
Publicado: (2012)

Complex relation of HLA-DRB1*1501, age at menarche, and age at multiple sclerosis onset
por: Bove, Riley, et al.
Publicado: (2016)

Long-Term Effect of Immediate Versus Delayed Fingolimod Treatment in Young Adult Patients with Relapsing–Remitting Multiple Sclerosis: Pooled Analysis from the FREEDOMS/FREEDOMS II Trials
por: Ghezzi, Angelo, et al.
Publicado: (2019)

Neurotrophic, Gene Regulation, and Cognitive Functions of Carboxypeptidase E-Neurotrophic Factor-α1 and Its Variants
por: Xiao, Lan, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ht5uhjldjtbanc9eroi6cs1645