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Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging

Adaptation of cardiac muscle to regular exercise results in morphological and structural changes known as physiological cardiac hypertrophy, to which the Hippo signaling pathway might have contributed. Two major terminal effectors in the Hippo signaling pathway are Yes-associated protein (YAP) and i...

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Autores principales: Limyati, Yenni, Sanjaya, Ardo, Lucretia, Teresa, Gunadi, Julia Windi, Biben, Vitriana, Jasaputra, Diana Krisanti, Lesmana, Ronny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896415/
https://www.ncbi.nlm.nih.gov/pubmed/35379136
http://dx.doi.org/10.2174/1573403X18666220404152924
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author Limyati, Yenni
Sanjaya, Ardo
Lucretia, Teresa
Gunadi, Julia Windi
Biben, Vitriana
Jasaputra, Diana Krisanti
Lesmana, Ronny
author_facet Limyati, Yenni
Sanjaya, Ardo
Lucretia, Teresa
Gunadi, Julia Windi
Biben, Vitriana
Jasaputra, Diana Krisanti
Lesmana, Ronny
author_sort Limyati, Yenni
collection PubMed
description Adaptation of cardiac muscle to regular exercise results in morphological and structural changes known as physiological cardiac hypertrophy, to which the Hippo signaling pathway might have contributed. Two major terminal effectors in the Hippo signaling pathway are Yes-associated protein (YAP) and its homolog transcriptional coactivator with PDZ-binding motif (TAZ). The latest studies have reported the role of YAP and TAZ in different life stages, such as in fetal, neonatal, and adult hearts. Their regulation might involve several mechanisms and effectors. One of the possible coregulators is exercise. Exercise plays a role in cardiomyocyte hypertrophic changes during different stages of life, including in aged hearts. YAP/TAZ signaling pathway has a role in physiological cardiac hypertrophy induced by exercise and is associated with cardiac remodelling. Thus, it can be believed that exercise has roles in activating the signaling pathway of YAP and TAZ in aged cardiomyocytes. However, the studies regarding the roles of YAP and TAZ during cardiomyocyte aging are limited. The primary purpose of this review is to explore the response of cardiovascular aging to exercise via signaling pathway of YAP and TAZ.
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spelling pubmed-98964152023-11-02 Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging Limyati, Yenni Sanjaya, Ardo Lucretia, Teresa Gunadi, Julia Windi Biben, Vitriana Jasaputra, Diana Krisanti Lesmana, Ronny Curr Cardiol Rev Cardiology Adaptation of cardiac muscle to regular exercise results in morphological and structural changes known as physiological cardiac hypertrophy, to which the Hippo signaling pathway might have contributed. Two major terminal effectors in the Hippo signaling pathway are Yes-associated protein (YAP) and its homolog transcriptional coactivator with PDZ-binding motif (TAZ). The latest studies have reported the role of YAP and TAZ in different life stages, such as in fetal, neonatal, and adult hearts. Their regulation might involve several mechanisms and effectors. One of the possible coregulators is exercise. Exercise plays a role in cardiomyocyte hypertrophic changes during different stages of life, including in aged hearts. YAP/TAZ signaling pathway has a role in physiological cardiac hypertrophy induced by exercise and is associated with cardiac remodelling. Thus, it can be believed that exercise has roles in activating the signaling pathway of YAP and TAZ in aged cardiomyocytes. However, the studies regarding the roles of YAP and TAZ during cardiomyocyte aging are limited. The primary purpose of this review is to explore the response of cardiovascular aging to exercise via signaling pathway of YAP and TAZ. Bentham Science Publishers 2022-09-16 2022-09-16 /pmc/articles/PMC9896415/ /pubmed/35379136 http://dx.doi.org/10.2174/1573403X18666220404152924 Text en © 2022 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Cardiology
Limyati, Yenni
Sanjaya, Ardo
Lucretia, Teresa
Gunadi, Julia Windi
Biben, Vitriana
Jasaputra, Diana Krisanti
Lesmana, Ronny
Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging
title Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging
title_full Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging
title_fullStr Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging
title_full_unstemmed Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging
title_short Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging
title_sort potential role of exercise in regulating yap and taz during cardiomyocytes aging
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896415/
https://www.ncbi.nlm.nih.gov/pubmed/35379136
http://dx.doi.org/10.2174/1573403X18666220404152924
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