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Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging
Adaptation of cardiac muscle to regular exercise results in morphological and structural changes known as physiological cardiac hypertrophy, to which the Hippo signaling pathway might have contributed. Two major terminal effectors in the Hippo signaling pathway are Yes-associated protein (YAP) and i...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896415/ https://www.ncbi.nlm.nih.gov/pubmed/35379136 http://dx.doi.org/10.2174/1573403X18666220404152924 |
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author | Limyati, Yenni Sanjaya, Ardo Lucretia, Teresa Gunadi, Julia Windi Biben, Vitriana Jasaputra, Diana Krisanti Lesmana, Ronny |
author_facet | Limyati, Yenni Sanjaya, Ardo Lucretia, Teresa Gunadi, Julia Windi Biben, Vitriana Jasaputra, Diana Krisanti Lesmana, Ronny |
author_sort | Limyati, Yenni |
collection | PubMed |
description | Adaptation of cardiac muscle to regular exercise results in morphological and structural changes known as physiological cardiac hypertrophy, to which the Hippo signaling pathway might have contributed. Two major terminal effectors in the Hippo signaling pathway are Yes-associated protein (YAP) and its homolog transcriptional coactivator with PDZ-binding motif (TAZ). The latest studies have reported the role of YAP and TAZ in different life stages, such as in fetal, neonatal, and adult hearts. Their regulation might involve several mechanisms and effectors. One of the possible coregulators is exercise. Exercise plays a role in cardiomyocyte hypertrophic changes during different stages of life, including in aged hearts. YAP/TAZ signaling pathway has a role in physiological cardiac hypertrophy induced by exercise and is associated with cardiac remodelling. Thus, it can be believed that exercise has roles in activating the signaling pathway of YAP and TAZ in aged cardiomyocytes. However, the studies regarding the roles of YAP and TAZ during cardiomyocyte aging are limited. The primary purpose of this review is to explore the response of cardiovascular aging to exercise via signaling pathway of YAP and TAZ. |
format | Online Article Text |
id | pubmed-9896415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-98964152023-11-02 Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging Limyati, Yenni Sanjaya, Ardo Lucretia, Teresa Gunadi, Julia Windi Biben, Vitriana Jasaputra, Diana Krisanti Lesmana, Ronny Curr Cardiol Rev Cardiology Adaptation of cardiac muscle to regular exercise results in morphological and structural changes known as physiological cardiac hypertrophy, to which the Hippo signaling pathway might have contributed. Two major terminal effectors in the Hippo signaling pathway are Yes-associated protein (YAP) and its homolog transcriptional coactivator with PDZ-binding motif (TAZ). The latest studies have reported the role of YAP and TAZ in different life stages, such as in fetal, neonatal, and adult hearts. Their regulation might involve several mechanisms and effectors. One of the possible coregulators is exercise. Exercise plays a role in cardiomyocyte hypertrophic changes during different stages of life, including in aged hearts. YAP/TAZ signaling pathway has a role in physiological cardiac hypertrophy induced by exercise and is associated with cardiac remodelling. Thus, it can be believed that exercise has roles in activating the signaling pathway of YAP and TAZ in aged cardiomyocytes. However, the studies regarding the roles of YAP and TAZ during cardiomyocyte aging are limited. The primary purpose of this review is to explore the response of cardiovascular aging to exercise via signaling pathway of YAP and TAZ. Bentham Science Publishers 2022-09-16 2022-09-16 /pmc/articles/PMC9896415/ /pubmed/35379136 http://dx.doi.org/10.2174/1573403X18666220404152924 Text en © 2022 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Cardiology Limyati, Yenni Sanjaya, Ardo Lucretia, Teresa Gunadi, Julia Windi Biben, Vitriana Jasaputra, Diana Krisanti Lesmana, Ronny Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging |
title | Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging |
title_full | Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging |
title_fullStr | Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging |
title_full_unstemmed | Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging |
title_short | Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging |
title_sort | potential role of exercise in regulating yap and taz during cardiomyocytes aging |
topic | Cardiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896415/ https://www.ncbi.nlm.nih.gov/pubmed/35379136 http://dx.doi.org/10.2174/1573403X18666220404152924 |
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