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Cell-free Biosynthesis of Peptidomimetics

A wide variety of peptidomimetics (peptide analogs) possessing innovative biological functions have been brought forth as therapeutic candidates through cell-free protein synthesis (CFPS) systems. A key feature of these peptidomimetic drugs is the use of non-canonical amino acid building blocks with...

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Detalles Bibliográficos
Autores principales: Lee, Kanghun, Willi, Jessica A., Cho, Namjin, Kim, Inseon, Jewett, Michael C., Lee, Joongoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Biotechnology and Bioengineering 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896473/
https://www.ncbi.nlm.nih.gov/pubmed/36778039
http://dx.doi.org/10.1007/s12257-022-0268-5
Descripción
Sumario:A wide variety of peptidomimetics (peptide analogs) possessing innovative biological functions have been brought forth as therapeutic candidates through cell-free protein synthesis (CFPS) systems. A key feature of these peptidomimetic drugs is the use of non-canonical amino acid building blocks with diverse biochemical properties that expand functional diversity. Here, we summarize recent technologies leveraging CFPS platforms to expand the reach of peptidomimetic drugs. We also offer perspectives on engineering the translational machinery that may open new opportunities for expanding genetically encoded chemistry to transform drug discovery practice beyond traditional boundaries.