Atomic Resolution Insights into pH Shift Induced Deprotonation Events in LS-Shaped Aβ(1–42) Amyloid Fibrils

[Image: see text] Alzheimer’s disease is a neurodegenerative disorder associated with the deposition of misfolded aggregates of the amyloid-β protein (Aβ). Aβ(1–42) is one of the most aggregation-prone components in senile plaques of AD patients. We demonstrated that relatively homogeneous Aβ(1–42)...

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Detalles Bibliográficos
Autores principales: Becker, Nina, Frieg, Benedikt, Gremer, Lothar, Kupreichyk, Tatsiana, Gardon, Luis, Freiburg, Patrick, Neudecker, Philipp, Willbold, Dieter, Gohlke, Holger, Heise, Henrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896559/
https://www.ncbi.nlm.nih.gov/pubmed/36653015
http://dx.doi.org/10.1021/jacs.2c09231

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